Monoclonal antibodies against N-Terminus proBNP

Details Monoclonal antibodies against N-Terminus proBNP Monoclonal antibodies against N-Terminus proBNP

2005-11-01

2005-11-01

Schwadron, Ronald B. (Department: 1644)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

C435S332000, C435S335000, C435S337000, C435S346000, C435S353000, C530S388200, C530S388230, C530S388240, C530S388250

Reexamination Certificate

active

06960472

ABSTRACT:
Monoclonal antibodies having high affinity for N-terminus pro brain natriuretic peptide (NT-proBNP) are described. The monoclonal antibodies are prepared against a synthetic peptide having the Sequence ID No. 1. Specifically, the monoclonal antibodies described are produced from two hybridoma cell lines, 6G11-F11-D12 and 1C3-E11-R9, deposited with the American Type Culture Collection under Accession Numbers PTA-4844 and PTA-4845 respectively. The monoclonal antibody antibodies can be used as reagents in an immunoassay system to identify blood, serum or plasma levels of NT-proBNP. Such an immunoassay system can be used for diagnosing and quantifying congestive heart failure (CHF).

REFERENCES:
patent: 5786163 (1998-07-01), Hall

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