Lactone integrin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S514000, C514S269000, C514S256000, C514S561000, C514S482000, C514S617000, C514S473000, C544S244000, C544S297000, C544S298000, C544S322000, C544S330000, C544S335000, C546S001000, C549S263000, C549S295000, C549S321000, C549S323000

Reexamination Certificate

active

06906051

ABSTRACT:
The present invention relates to a class of compounds represented by the Formula I:or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αVβ3and/or the αVβ5integrin.

REFERENCES:
patent: 5602155 (1997-02-01), Ruminski
patent: 6013651 (2000-01-01), Rogers et al.
patent: 6028223 (2000-02-01), Ruminski et al.
patent: 6211191 (2001-04-01), Duggan et al.
patent: 6720327 (2004-04-01), Ruminski et al.
patent: 0641800 (1994-01-01), None
patent: 9708145 (1997-03-01), None
U.S. Appl. No. 10/381,834, filed Aug. 23, 2003.
Cecil Textbook of Medicine,20thEdition, vol. 1,1004-10(1996).
Uckun et al, Current cancer Drug Targets,1/1,59-71(2001).
PubMed 12082286,also cited as Biorheology,39/1-2,237-46(2002).
PubMed Abstract 12851778,also cited as Acta Neuropathol.(Berl) 106/4,319-22(2003).
PubMed Abstract 12234368,also cited as Immunol. Rev. 186, 125-40(2002).
PubMed Abstract 14718670, also cited as Proc. Natl. Acad. Sci.USA, 101/3,763-8(2004).
PubMed Abstract 10723092, also cited as Cell Biochem. 77/2,265-76(2000).
PubMed Abstract 12657612, also cited as Invest. Ophthalmol. Vis. Sci. 44/4,1704-15(2003).
Carron, et al.,Cancer Research; V. 58, No. 9: pp. 1930-1935; 1998.
Lark, et al.,Journal of Bone&Mineral Research; V. 16, No. 2: pp. 319-327; 2000.
Healy, et al.,Human Reproductive Update; V. 4: pp. 136; 1998.
Cheresh,Cancer Metastasis Review; V. 10: pp. 3-10; 1991.
Brooks, et al.,Cell; V. 79, No. 7: pp. 1157-1164; 1994.
Friedlander, et al.,Proceedings Of The National Academy Of Science USA; V. 93, No. 18; pp. 9764-9769; 1996.
Badger, et al.,Arthritis&Rheumatism; V. 44, No. 1: pp. 128-137; 2001.
Brown,Cardiovascular Research; V. 28; pp. 1815-; 1994.
Friedlander, et al.,Science; V. 270 (5241): pp. 1500-1502; 1995.
Agrez, et al.,Journal of Cell Biology; V. 127, No. 2: pp. 547-556; 1994.
Christofidou-Solomidou, et al.,American Journal of Pathology; V. 151 (4): pp. 975-983; 1997.
Seftor, et al.,Proceedings of the National Academy of Science USA; V. 89: pp. 1557-1561;Mar. 1992.
Montgomery, et al.,Proceedings of the National Academy of Science USA; V. 91: pp. 8856-8860; Sep. 1994.
Adamis, et al.,American Journal of Ophthalmology; V. 118: pp. 445-450; 1994.
Peacock, et al.,Journal of Experimental Medicine; V. 175: pp. 1135-1138; 1992.
Brooks, et al.,Science; V. 264: pp 569-571; 1994.
Sato, et al.,Journal of Cell Biology; V. 111: pp. 1713-1723; 1990.
Fisher, et al.,Endocrinology; V. 132: pp. 1411-1413; 1993.
Choi, et al.,Journal of Vascular Surgery; V. 19(1): pp. 125-134; 1994.
White,Current Biology; V. 3(9): pp 596-599; 1993.
Rodriquez, et al.,Tetrahedron Letters; V. 32(7): pp. 923-926; 1991.
Design in Prodrugs, H. Bundgaard, editor; Elsevier; 1985.
Pytela, et al.,Methods in Enzymology, V. 144: pp. 475-489; 1987.
Yatohgo, et al.,Cell Structure&Function; V. 13: pp. 281-292; 1988.
Charo, et al.,Journal of Biological Chemistry; V. 266(3): pp. 1415-1421; 1991.
Niya, et al.,Blood, V. 70(2): pp. 475-483; 1987.
Rodbard, et al.,International Atomic Energy Agency, Vienna; pp 469-; 1977.
Zucker,Methods in Enzymology; V. 169; pp. 117-133; 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Lactone integrin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lactone integrin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lactone integrin antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3467928

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.