Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-05-30
1992-08-11
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548313, 548312, 514391, A61K 31415, C07D23300
Patent
active
051379040
ABSTRACT:
A series of ethers and thioethers of 5-methanol thiohydantoins, unsubstituted at the number one position heterocyclic nitrogen atom of the thiohydantoin ring, useful in reversing the effects of collagen and ADP-induced platelet aggregation.
REFERENCES:
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Matsueda, et al. Quantitative solid-phase Edman degradation for evaluation of extended solid-phase peptide synthesis. Biochemistry, 1981, pp. 2571-2580.
Rochat, et al. S-L Alkyl derivatives of cysteine suitable for sequenced determination by the phenylisothiocyanate technique. Anal. Biochem. 1970, 37(2), 259-67.
Steinman, et al. Synthesis of side chain-protected amino acid phenylthiohydantoins and their use in quantitative solid-phase Edman degradation. Anal. Biochem. 1985, 145(1), 91-5.
Tschesche, et al. Mass spectral identification and quantification of phenylthiohydantoin derivatives from Edman degradation or proteins. FEBS letters, 1972, 23(3), 367-72.
Hopp, Thomas. Identification of aqueous phase amino acid phenylthiohydantoins on polyamide sheets. Anal. Biochem. 1976, 74(2), 638-40.
Mak, et al. Application of S-pyridylethylato in of cysteine to the sequence analysis of proteins. Anal. Biochem. 1978, 84(2), 432-40.
Baran John S.
Lindberg Tom
Mazur Robert H.
Moorman Alan E.
Steinman Doug
G. D. Searle & Co.
Lee Mary C.
Matukaitis Paul D.
Serauskas Joy Ann
Whittenbaugh Robert C.
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