Substituted biaryl amides as C5a receptor modulators

Details Substituted biaryl amides as C5a receptor modulators Substituted biaryl amides as C5a receptor modulators

2005-02-22

2005-02-22

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S427000, C514S461000, C548S338100, C548S561000, C568S054000, C549S496000

Reexamination Certificate

active

06858637

ABSTRACT:
Substituted biaryl amides of Formula I are provided. Such compounds are ligands that may be used to modulate C5areceptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological C5areceptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

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Arumugam et al. (2002)Journal of Surgical Research103:260-67.

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