Process for producing α-aminoketones

Details Process for producing α-aminoketones Process for producing α-aminoketones

2005-06-14

2005-06-14

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S496000, C549S513000, C549S514000

Reexamination Certificate

active

06906224

ABSTRACT:
A process for producing α-aminohalomethyl ketones or N-protected α-aminohalomethyl ketones from specified 3-oxazolidin-5-one derivatives via 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. By this process, α-aminohalomethyl ketones and compounds relating to them can be obtained efficiently and economically in industrial scale.

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Magnus W. Walter, et al., “Reaction of (Trifluoromethyl) Trimethylsilane with Oxazolidin-5-Ones: Synthesis of Peptidic and Nonpeptidic Trifluoromethyl Ketones”, J. Organic Chemistry, (1998), 63, pp. 5179-5192.
Magnus W. Walter, et al., “Reaction of Ruppert's Reagent (TMS-CF3) with Oxazolidinones: Synthesis of Protected Alpha-Amino Trifluoromethylketones”, Tetrahedron Letters, vol. 36, No. 42, pp. 7761-7764 (1995).

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