Process for producing optically active amide from α...

Details Process for producing optically active amide from α... Process for producing optically active amide from α...

2005-02-15

2005-02-15

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S218000, C564S219000, C560S170000

Reexamination Certificate

active

06855847

ABSTRACT:
A novel process for producing an optically active amide excellent in chemical selectivity and enantioselectivity by asymmetric hydrogenation of an α,β-unsaturated amide and also allowing the reaction to proceed efficiently even when a trace amount of a catalyst is used relative to the substrate as compared with the amount in a conventional process. An optically active amide is produced by asymmetric hydrogenation of an α,β-unsaturated amide derivative in the presence of a transition metal complex containing a specific phosphine-phosphorane compound.

REFERENCES:
patent: 6492544 (2002-12-01), Krimmer et al.
patent: 6624320 (2003-09-01), Matsumura et al.
patent: 6730629 (2004-05-01), Matsumura et al.
patent: 20030139285 (2003-07-01), Matsumura et al.
patent: 1 103 536 (2001-05-01), None
patent: WO 9117998 (1991-11-01), None
patent: WO 9301199 (1993-01-01), None
patent: WO 9959721 (1999-11-01), None
patent: WO 0011008 (2000-03-01), None
patent: WO 0026220 (2000-05-01), None
Burk et al, Organic Letters, vol. 1, No. 3, pp 387-390, 1999.*
Gridnev et al, J. Am. Chem. Soc., vol. 122, pp 10486-10487, 2000.*
Yan et al, Organic Letters, vol. 2, No. 26, pp 4137-4140, 2000.*
Henri Brunner et al., XXXIII *. New Optically Active Phospholanes Derived From Tartaric Acid**, Journal of Organometallic Chemistry, 328 (1987) pp. 71-80.
Jens Holz et al, Synthesis of a New Class of Functionalized Chiral Bisphospholane Ligands and the Application in Enantioselective Hydrogenations, J. Org. Chem. 1998, 63, pp. 8031-8034.
Konstantin Kottsieper et al., Synthesis of Enantiopure C1Symmetric Diphosphines and Phosphino-Phosphonites with Ortho-Phenylene Backbones, Tetrahedron: Asymmetry 12 (2001) pp. 1159-1169.
Konstantin W. Kottsieper et al., Synthesis of enantiopure C1symmetric diphosphines and phosphino-phosphonites with ortho-phenylene backbones, Tetrahedron: Asymmetry 21 (2001), pp. 1159-1169.
Guoxin Zhu et al., Highly Efficient Asymmetric Synthesis of β-(Acylamino) acrylates, J. Org. Chem. 1999, 64, pp. 6907-6910.
European Search Report dated Dec. 9, 2002.

Affiliated with

Also associated with

Rating

Process for producing optically active amide from α... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing optically active amide from α..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing optically active amide from α... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3462449