Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-11-08
2005-11-08
Davis, Zinna Northington (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S617000, C546S314000, C564S182000
Reexamination Certificate
active
06962934
ABSTRACT:
The present invention relates to compounds of formula (I):useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
REFERENCES:
patent: 5362912 (1994-11-01), Sowin et al.
patent: 5696270 (1997-12-01), Kempf et al.
patent: 5892052 (1999-04-01), Kempf et al.
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6150530 (2000-11-01), Kempf et al.
patent: WO 00/06559 (2000-02-01), None
patent: 2000/77030 (2000-12-01), None
Kempf, et al., “Symmetry-Based Inhibitors of HIV Protease. Structure-Activity Studies of Acylated 2,4-Diamino-1,5-diphenyl-3-hydroxypentane and 2,5-Diamino-1,6-diphenylhexane-3,4-diol,”J. Med. Chem.36:320-330 (1993).
Kang, et al., “Synthesis of 1,4-Diaminocyclitols From└-Serine Methyl Ester,”J. Org. Chem.61:5528-5531 (1996).
Benedetti, et al., “Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units ofPseudopeptide HIV Protease Inhibitors,”J. Org. Chem.62:9348-9353 (1997).
Zuccarello, et al., “HIV-1 Protease Inhibitors Based on Acyclic Carbohydrates,”J. Org. Chem.63:4898-4906 (1998).
Lee, et al., “Development of a New Type of Protease Inhibitors, Efficacious against FIV and HIV Variants,”J. Am. Chem. Soc.121:1145-1155 (1999).
Jagodzinska Barbara
Warpehoski Martha A.
Davis Zinna Northington
Elan Pharmaceuticals Inc.
McDonnell Boehnen Hulbert & Bergohoff LLP
Pharmacia & Upjohn Company
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