Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1995-06-13
1998-08-25
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424472, 6048901, 6048921, A61K 922, A61K 924, A61K 932, A61K 934
Patent
active
057981191
ABSTRACT:
An osmotic device that, following the imbibition water vapor, provides for the controlled release of a beneficial agent to a non-aqueous environment. The device comprises a hydrophilic formulation and a beneficial agent, surrounded by a wall. The wall is formed at least in part of a semipermeable hydrophobic microporous membrane having an average pores size between about 0.1 .mu.m and 30 .mu.m. The pores are substantially filled with a gas phase. The hydrophobic membrane is permeable to water in the vapor phase and the hydrophobic membrane is impermeable to an aqueous medium at a pressure less than about 100 Pa. The beneficial agent is released, for example, by osmotic pumping or osmotic bursting upon imbibition of sufficient water vapor into the hydrophilic formulation. The high water fluxes attendant with these vapor-permeable hydrophobic membranes facilitate the delivery of large quantities of beneficial agents without requiring large surface areas (quantities) of hydrophobic microporous membrane. In addition, use of vapor-permeable hydrophobic microporous membranes allow osmotic devices to be used in environments having limited water availability, such as air or soil.
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Herbig Scott M.
Miller Eric J.
Page Thurman K.
S. C. Johnson & Son Inc.
Spear James M.
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