Microplate thermal shift assay apparatus for ligand...

Chemistry: analytical and immunological testing – Peptide – protein or amino acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S147000, C436S501000, C436S518000, C435S007100

Reexamination Certificate

active

06849458

ABSTRACT:
The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a predetermined profile.

REFERENCES:
patent: 4580895 (1986-04-01), Patel
patent: 4626684 (1986-12-01), Landa
patent: 4628026 (1986-12-01), Gardell et al.
patent: 4774055 (1988-09-01), Wakatake et al.
patent: 4778763 (1988-10-01), Makiguchi et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5255976 (1993-10-01), Connelly
patent: 5290513 (1994-03-01), Berthold et al.
patent: 5314825 (1994-05-01), Weyrauch et al.
patent: 5324635 (1994-06-01), Kawase et al.
patent: 5340747 (1994-08-01), Eden
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5383023 (1995-01-01), Walleczek
patent: 5415839 (1995-05-01), Zaun et al.
patent: 5436718 (1995-07-01), Fernandes et al.
patent: 5463564 (1995-10-01), Agrafiotis et al.
patent: 5496519 (1996-03-01), Schacher
patent: 5525300 (1996-06-01), Danssaert et al.
patent: 5557398 (1996-09-01), Wechsler et al.
patent: 5585277 (1996-12-01), Bowie et al.
patent: 5589351 (1996-12-01), Harootunian
patent: 5599504 (1997-02-01), Hosoi et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5679582 (1997-10-01), Bowie et al.
patent: 6020141 (2000-02-01), Pantoliano et al.
patent: 6036920 (2000-03-01), Pantoliano et al.
patent: 6214293 (2001-04-01), Pantoliano et al.
patent: 6232085 (2001-05-01), Pantoliano et al.
patent: 6268158 (2001-07-01), Pantoliano et al.
patent: 6268218 (2001-07-01), Pantoliano et al.
patent: 6291191 (2001-09-01), Pantoliano et al.
patent: 6291192 (2001-09-01), Pantoliano et al.
patent: 6303322 (2001-10-01), Pantoliano et al.
patent: 6569631 (2003-05-01), Pantoliano et al.
patent: 0 512 334 (1992-11-01), None
patent: 0 640 828 (1995-03-01), None
patent: WO 9405394 (1994-03-01), None
patent: WO 9815969 (1998-04-01), None
Phase II Grant Application for Michael Pantoliano for Automated Receptor Screening by Themal Physical Assays, Department of Health and Human Services Form PHS-6246-2, Dec. 14, 1995.
“Temperature Cyclers: Robocycler Gradient Temperature Cyclers”, Stratagene Product Catalog, 1997-1998, pp. 236-237.
Schellman, J.A., “Communicatios to the Editor: The Effect of Binding on the Melting Temperature of Biopolymers”, Biopolymers, 1976, pp. 999-1000, vol. 15, No. 5, John Wiley & Sons.
Tsai, P.K. et al., “Formulation Design of Fibroblast Growth Factor”, Pharmaceutical Research, May 1993, pp. 649-659, vol. 10, No. 5, Plenum Publishing.
Volkin, D.B. et al., “Physical Stabilization of Acidic Fibroblast Growth Factor by Polyanions”, Archives by Biochemistry and Biophysics, Jan. 1993, pp. 30-41, vol. 300, No. 1, Academic Press.
Waring, M.J., “Stabilization of Two-Stranded Ribohomopolymer Helices and Destabilization of a Three-Stranded Helix by Ethidium Bromide”, The Biochemical Journal: Molecular Aspects, 1974, pp. 483-486, London: The Biochemical Society.
Waring, M.J. and Henley, S.M., “Stereochemical Aspects of the Interaction Between Asteroidal Diamine and DNA”, Nucleic Acids Research, Apr. 1975, pp. 567-586, vol. 2, No. 4, Information Retrieval Ltd.
Weber, P.C. et al., “Structural-Based Design of Synthetic Azobenzene Ligands for Streptavidin”, J. Am. Chem. Soc., 1994, pp. 2717-2724, vol. 116, American Chemical Society.
Volkin et al., “The Effect of Polyanions on the Stabilization of Acidic Fibroblast Growth Factor”, Harnessing Biotechnology for the 21st Century, ed. Ladisch, M. and A. Bose, 1992, pp. 144-168.
Cytocalc Data Analysis System User's Guide, PerSeptive Biosystems, Apr. 1995.
CytoFluor UU Fluorescence Multi-Well Plate Reader User's Guide, PerSpetive Biosystems, Aug. 1995.
Phase I Grant Application for Michael Pantoliano for Automated Receptor Screening by Thermal Physical Assays, Department of Health and Human Services Form PHS-6246-1, Aug. 11, 1994.
Brandts, J.F. and Lin, L., “Study of Strong to Ultralight Protein Interactions Using Differential Scanning Calorimetry”, Biochemistry, 1990, pp. 6927-6940, vol. 29, No. 29., American Chemincal Society.
Chavan, A.J. et al., “Interaction of Nucleotides with Acidi Fibroblast Growth Factor (FGF-1”, Biochemistry, 1994, pp. 7193-7202, vol. 33, No. 23, American Chemical Society.
Eftnik, M.R., “The Use of Fluroscence Methods toMonitor Unfolding Transitions in Proteins”, Biophysical Journal, Feb. 1994, pp. 482-501, vol. 66, No. 2, Biophysical Society.
Freire, E., “Thermal Denaturation Methods in the Study of Protein Folding”, Methods in Enzymology: Energetics of Biological Macromolecules, 1995, pp. 144-168, vol. 259, Academic Press.
Haff, L. et al., “A High-Performance System for Automation of the Polymerase Chain Reaction”, Biotechniques, Jan. 1991, pp. 102-112, vol. 10, No. 1, Eaton Publishing.
Higuchi, R., et al., “Kinetic PCR Analysis: Real-time Monitoring of DNA Amplification Reactions”, BIO/Technology, Sep. 1993, pp. 1026-1030, vol. 11, Nature-Publishing.
Higuchi, R., et al., “Simultaneous Amplification and Detection of Specific DNA Sequences”, BIO/Technology, Apr. 1992, pp. 413-417, vol. 10, No. 4, Nature Publishing.
Morton, A. et al., “Energetic Origins of Specialty of Ligand Binding in an Interior Nonpolar Cavity of T4 Lysozyme”, Biochemistry, 1995, pp. 8564-8574, vol. 34, No. 27, American Chemical Society.
Pilch, D.S. et al., “Ligand-Induced Formation of Nucleic Acid Triple Helices”, Proceedings of the National Academy of Sciences of the USA, Sep. 1994, pp. 9332-9336, vol. 91, No. 20.
Ramsay, G. and Eftnik, M.R., “A Multidimensional Spectrophotometer for Monitoring Thermal Unfolding Transitions of Macromolecules”, Biophysical Journal, Feb. 1994, pp. 516-523, vol. 31, The Biophysical Society.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Microplate thermal shift assay apparatus for ligand... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Microplate thermal shift assay apparatus for ligand..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Microplate thermal shift assay apparatus for ligand... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3455806

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.