Process for the production of carnitine

Details Process for the production of carnitine Process for the production of carnitine

1975-09-25

1977-05-03

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260482R, 260632A, C07C 9900

Patent

active

040214800

ABSTRACT:
The process for the production of carnitine hydrochloride which involves reacting an ester of .gamma.-halo-acetoacetic acid having the formula: ##STR1## R.sub.1 is a hydrogen, R.sub.2 is a lower alkyl group having 1 to 10 carbon atoms and X is halogen selected from the group consisting of chlorine or bromine, with an alkali alcoholate, which is present in a stoichiometrically excessive amount, at a temperature between 0.degree. and -40.degree. C. The reaction product is reacted with trimethylamine at a temperature between 10.degree. and 50.degree. C., a (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide is hydrogenated, a carnitine ester resulting. Then the carnitine ester is converted by means of aqueous hydrochloride acid into carnitine hydrochloride.

REFERENCES:
patent: 2530627 (1950-11-01), Pfister et al.
patent: 2933522 (1960-04-01), Cramer et al.
patent: 3038007 (1962-06-01), Reeve
patent: 3135788 (1964-06-01), Noguchi et al.
D'Alo et al., "Chem. Abstracts," vol. 60 (1964), Cols. 10777, 10778.

Affiliated with

Also associated with

Rating

Process for the production of carnitine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of carnitine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of carnitine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-345573