Process for the preparation of L-phosphinothricine by...

Details Process for the preparation of L-phosphinothricine by... Process for the preparation of L-phosphinothricine by...

2005-08-30

2005-08-30

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

C435S128000

Reexamination Certificate

active

06936444

ABSTRACT:
The patent application describes a process for the enzymatic chiral synthesis of L-phosphinothricin by transamination from its corresponding keto acid PPO with aspartate as amino donor. It is possible by a suitable reaction procedure to achieve a quantitative conversion on use of approximately equimolar amounts of amino donor and acceptor with complete consumption of the donor amino acid aspartate. The use of thermally stable transaminases makes a higher reaction rate and correspondingly large space/time yields possible.

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Bartsch, et al., “Stereospecific production of the herbicide phosphinothricin (glufosinate): purification of aspartate transaminase fromBacillus stearothermophilus, cloning of the corresponding gene, aspC, and application in a coupled transaminase process,” Appl. Environ. Microbiol., Oct. 1996, vol. 62 No. 10 pp. 3794-3799.
Fotheringham, et al., “Biocatalytic production of unnatural amino acids, mono esters and N-protected derivatives,” Chimica Oggi/Chemistry Today, Sep./Oct. 1997, pp. 33-37.
Taylor, et al., “Novel biosynthetic approaches to the production of unnatural amino acids using transaminases,” Tibtech, Oct. 1998, vol. 16, pp. 412-418.

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