Mixtures of drug-oligomer conjugates comprising polyalkylene...

Details Mixtures of drug-oligomer conjugates comprising polyalkylene... Mixtures of drug-oligomer conjugates comprising polyalkylene...

2005-02-22

2005-02-22

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C514S021800, C530S345000, C530S410000, C424S193100, C568S613000, C568S618000, C568S622000

Reexamination Certificate

active

06858580

ABSTRACT:
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.

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