Immunogobulin conjugates

Details Immunogobulin conjugates Immunogobulin conjugates

1995-04-11

1998-08-25

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241781, 4241791, 5303917, 5303919, A61K 39395, A61K 3944, C07K 1600, C07K 1700

Patent

active

057980977

ABSTRACT:
Immunoglobulin conjugates, comprising idarubicin (Ida) conjugated to a monoclonal antibody or fragment thereof comprising at least one of the antigen binding sites of the antigen, are useful for treating a human or other animal suffering from a cancer or for depleting a subset of T lymphocytes from a population of cells.

REFERENCES:
patent: 4077988 (1978-03-01), Arcamone et al.
patent: 4867973 (1989-09-01), Goers et al.
patent: 4950738 (1990-08-01), King et al.
Osband et al (1990) Immunology Today 11(6):193-195.
Gould et al (1989) J. Natl. Cancer Inst. 81(10):775-781.
Harris et al (1993) TIBTECH 11:42-44.
Hermentin et al (1988) Behring Inst. Mitt. No. 82:197-215.
Waldmann (1991) Science 252:1657-1662.
Sally Seaver (1994) Aug. issue of Genetic Engineering News pp. 10 and 21.
Pastan et al 47:641-648 of Cell1986.
E. Diener et al. (1986) Science 231: 148-150.
J. Gallego et al. (1984) Int. J. Cancer 33: 737-744.
S. Xie et al. (1987) Transplantation 44:770-774.
Pietersz; Smyth; McKenzie--Cancer Res (U.S.A) 1988 48/4 pp. 926-931 Coden CNREA.
Pietersz; Smyth: McKenzie, J. Natl. Cancer. Inst. (U.S.A.) 1987 pp. 1367-1373, Coden JNCIA.
Gerbino: Am Drug (U.S.A.) 1984 190/2 pp. 58-64 Coden AMDRA.
Antibody, Immunconjugates and Radiopharmaceuticals, vol. 1, No. 1, 1988, pp. 79-102, Mary Ann Liebert Inc. Publishers; g.A. Pietersz et al.: Preclinical and clinical studies with a variety of immunoconjugates . . . .
Transplantation, vol. 46, No. 1, juillet 1988 pp. 126-131, US; M.J. Smyth et al.: Immunosuppression of graft rejection with . . . .
Br. J. Cancer, vol. 47, 1983, C.H. Thompson et al: "Monoclonal antibodies to human colon and colorectal carcinoma".

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