Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2005-02-15
2005-02-15
Kunz, Gary (Department: 1647)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
C436S503000, C436S504000, C435S007100, C435S007200, C435S007210, C530S351000
Reexamination Certificate
active
06855560
ABSTRACT:
DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
REFERENCES:
patent: 5817480 (1998-10-01), Murry et al.
patent: 5882893 (1999-03-01), Goodearl
patent: 6136559 (2000-10-01), Lovenberg et al.
patent: 6413743 (2002-07-01), Lovenberg et al.
patent: 6437100 (2002-08-01), Lovenberg et al.
patent: 1 043 395 (2000-10-01), None
patent: WO 9928470 (1999-06-01), None
Cherifi et al. Purification of a Histamine H3 Receptor Negatively Coupled to Phosphinositide Turnover in the Human Gastric Cell Line HGT1. The Journal of Biological Chemistry. vol. 267, No. 35, pp. 25315-25320, 1992.*
Gespach et al. European Journal of Clinical Investigation, vol. 19, pp. 1-10, 1988.*
Coge et al. Genomic Organization and Characterization of Splice Variants of the Human Histamine H3 receptor. Biochemical Journal, vol. 355, pp. 279-288. 2001.*
Arrang, J. M., M. Garbarg, et al. (1983). “Autoinhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.”Nature (London)302(5911): 832-7.
Clark, M. A., A. Korte, et al. (1993). “Guanine nucleotides and pertussis toxin reduce the affinity of histamine H3 receptors on AtT-20 cells.”Agents Actions40(3-4): 129-34.
Clark, M. A., A. Korte, et al. (1992). “High affinity histimine H3 receptors regulate ACTH release by AtT-20 cells.”Eur. J. Pharmacol.210(1):31-5.
Gantz, I., M. Schaffer, et al. (1991). “Molecular cloning of a gene encoding the histimine H2 receptor.”Proc. Natl. Acad. Sci. U. S. A.88(2): 429-33.
Hill, S. J., C. R. Ganellin, et al. (1997). “International Union of Pharmacology. XIII. Classification of histamine receptors.”Pharmacol. Rev.49(3): 253-278.
Konig, M., L. C. Mahan, et al. (1991). “Method for identifying ligands that bind to cloned Gs-or Gi-coupled receptors.”Mol. Cell. Neurosci.2(4): 331-7.
Lovenberg, Timothy W.; Roland, Barbara L.; Wilson, Sandy J.; Jiang, Xiaoxia; Pyati, Jayashree; Huvar, Arne; Jackson, Michael R.; Erlander, Mark G. “Cloning and Functional Expression of the Human Histamine H3Receptor.” Molecular Pharmacology, 55:1101-1107, 1999.
Pollard, H., J. Moreau, et al. (1993). “A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas.”Neuroscience (Oxford)52(1): 169-89.
Yamashita, M., H. Fukui, et al. (1991). “Expression cloning of a cDNA encoding the bovine histimine H1 receptor.”Proc. Natl. Acad. Sci. U. S. A.88(24): 11515-19.
Lovenberg et al., “Cloning of Rat Histimine H3 Receptor Reveals Distinct Species Pharmacological Profiles” JPET. Feb. 2000, vol. 293, No. 3, pp. 771-778.
Backer, M.D. et al., “Genomic Cloning, Heterologous Expression and Pharmacological Characterization of a Human Histamine H1 Receptor”,Biochemical and Biophysical Research Communications, Dec. 1993, 197(3), 1601-1608.
Bellon, et al., “Purification and Biochemical Characterization of Recombinant Hirudin Produced by Saccharomyces Cerevisiae”,Biochem, 1989, 28, 2941-2949.
Ecker, et al., “Increasing Gene Expression in Yeast by Fusion to Ubiquitin”,J. Biol. Chem, 1989, 264(13), 7715-7719.
Horowitz, et al., “Synthesis and Assembly of Functional Mammalian Na, K-ATPase in Yeast”,J. Biol. Chem. 1990, 265(8), 4189-4192.
Jacobson, et al., “Expression and Secretion of Biologically Active Echistatin in Saccharomyces Cerevisiae”,Gene, 1989, 85(2), 511-516.
Jaso-Freidmann Liliana et al., “NCCRP-1: A Novel Receptor Protein Sequenced from Teleost Nonspecific Cytotoxic Cells”,Molecular Immunology, 1997, 34, 12-13), 955-965, XP002228234.
Kaufman, R.J. et al., “Amplification and Expression of Sequences Contransfected with a Modular Dihydrofolate Reductase Complementary DNA Gene”,J. Mol. Biol., 1982, 159, 601-621.
Kitts, et al., “Linearization of Baculovirus DNA Enhances the Recovery of Recombinant Virus Expression Vectors”,Nuc. Acid. Res., 1990, 18(19), 5667-5672.
Kohler, G. et al., “Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity”,Nature,, 1975, 256, 495-497.
Leurs, R. et al., “Therapeutic Potential of Histamine H3 Receptor Agonists and Antagonist”,Trends in Pharmacological Sciences, Elsevier Trends Journal, 1998, 19(5), 177-184, XP 004121095.
Leurs, R. et al., “Pharmacological Characterization of the Human Histamine H2 Receptor Stably Expressed in Chinese Hamster Ovary Cells”,British Journal of Pharmacology, 1994, 112, 847-853, XP 002916164.
Leurs, R. et al., “The Histamine H3-Receptor: A Target for Developing New Drugs”,Prog. Drug. Res., 1992, 39, 127-165.
McDonnell, et al., “Reconstitution of the Vitamin D-Responsive Osteocalcin Transcription Unit in Saccharomyce Cerevisiae”,Mol. Cell. Biol., 1989, 9(8), 3517-3523.
Rinas, et al., “Characterization of Recombinant Factor XIIIa Produced in Saccharomyces Cerevisiae”,Bio/Technology, 1990, 8(6), 543-546.
Sabin, et al., “High-Level Expression and In Vivo Processing of Chimeric Ubiquitin Fusion Proteins in Saccharomyces Cerevisiae”,Bio/Technology, 1989, 797), 705-709.
Sieckevitz, et al., “Activation of the HIV-1 LTR by T Cell Mitogens and the Trans-Activator Protein HTLV-1”,Science, 1987, 238, 1575-1578.
Sleep, et al., “The Secretion of Human Serum Albumin from the Yeast Saccharomyces Cerevisiae Using Five Different Leader Sequences”,BioTechnology, 1990, 8, 42-46.
Tedford, et al., “Development of Trans-2-[1H-imidazol-4-yl] Cyclopropane Derivatives as New High-Affinity Histamine H3 Receptor Ligands”,J. Pharmacol. Exper. Therapeutics, 1999, 289(2), 1160-1168.
Wigler, et al., “Transfer of Purified Herpes Virus Thymidine Kinase Gene to Cultured Mouse Cells”,Cell, 1977, 11(1), 223-232.
Yamamoto, et al., “Important Role of the Proline Residue in the Signal Sequence that Directs the Secretion of Human Lysozyme in Saccharomyces Cerevisiae”,Biochemistry, 1989, 28(6), 2728-2732.
Erlander Mark
Huvar Arne
Lovenberg Timothy W.
Pyati Jayashree
Hamud Fozia
Kunz Gary
Ortho -McNeil Pharmaceutical, Inc.
Woodcock & Washburn LLP
LandOfFree
Method of identifying compounds that modulate human... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of identifying compounds that modulate human..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of identifying compounds that modulate human... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3447809