Tricyclic diterpene derivatives

Details Tricyclic diterpene derivatives Tricyclic diterpene derivatives

2005-04-19

2005-04-19

Gitomer, Ralph (Department: 1651)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S116000, C562S498000, C562S499000, C514S510000, C514S577000

Reexamination Certificate

active

06881857

ABSTRACT:
Disclosed herein are novel tricyclic diterpene compounds. These compounds, including their prodrug esters and acid-addition salts, are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases.Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of the novel compounds that are useful as anti-inflammatory analgesics, in treating immune disorders, as anti-cancer and anti-tumor agents, and in the treatment of cardiovascular disease, skin redness, and viral infection. Completely synthetic and semi-synthetic methods of making the compounds and their analogs are also disclosed, as are methods of using these synthetic and semi-synthetic compounds in the treatment of the above-listed disease states.

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