Substituted carbazoles as inhibitors of sPLA2

Details Substituted carbazoles as inhibitors of sPLA2 Substituted carbazoles as inhibitors of sPLA2

2005-08-23

2005-08-23

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S441000

Reexamination Certificate

active

06933313

ABSTRACT:
Carbazoles of formula (I) with R2=hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.

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Dillard, et al., “Indole inhibitors of human nonpancreatic secretory phospholipase A21. Indole-3-acetamides,” Journal of Medicinal Chemistry, American Chemical Society, vol. 39, No. 26, pp. 5119-5136; XP002046054, Dec. 1, 1996.
Bernard, et al., “A molecular modeling and 3D QSAR study of a large series of indole inhibitors of human non-pancreatic secretory phospholipase A2,” European Journal of Medicinal Chemistry, Editions Scientifique Elsevier, vol. 36, No. 1, pp. 1-19; XP004317457, 2001.

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