Corticotropin releasing factor antagonists

Details Corticotropin releasing factor antagonists Corticotropin releasing factor antagonists

2005-01-18

2005-01-18

Jones, Dwayne (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S256000, C514S332000, C514S336000, C514S344000, C514S345000, C514S352000, C514S357000, C544S298000, C544S332000, C544S334000

Reexamination Certificate

active

06844351

ABSTRACT:
Corticotropin-releasing factor (CRF) antagonists having the formulaewherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16and R17are as defined in the application, and processes for preparing them. These compounds and their pharmaceutically acceptable salts are useful in the treatment disorders including CNS and stress-related disorders.

REFERENCES:
patent: 4605642 (1986-08-01), Rivier et al.
patent: 4839353 (1989-06-01), Hosoi et al.
patent: 5063245 (1991-11-01), Abreu et al.
patent: 5691364 (1997-11-01), Buckman et al.
patent: 3145287 (1983-05-01), None
patent: 0475411 (1992-03-01), None
patent: 0482804 (1997-01-01), None
patent: 0773023 (1997-05-01), None
patent: 0951906 (1999-10-01), None
patent: 1040831 (2000-04-01), None
patent: 1059100 (2000-12-01), None
patent: WO 94135676 (1994-06-01), None
patent: WO 9533750 (1995-12-01), None
patent: 9533750 (1995-12-01), None
Chhabria etal, Heterocycles, vol. 51, No. 11, 1999.
Kamel et al, Pharmazie 1990, 45 (2), 139-140.
Demina et al., Khim. Farm. Zh., 1993, 27(7), pp. 34-35 (with English summary).
Demina et al., Geterotsikl Soedin, 192 (11), pp. 1506-1508 (with English summary).
Chalmers, D. T., et al., Corticotrophin-releasing factors molecular biology to drug design. Trends in Pharmacological Sciences, (1996), vol. 17, pp. 166-172.
Cossey, A. L., et al. “Pyridines & Pyridinium Salts from Cyanocetamides” Australian Journal of Chem. (1976), 29 , p. 1039-50.
Owens, et al., “Physiology and Pharmacology of Corticotropin-releasing factor”, Pharm. Rev., (1991), vol. 43, pp. 425-473.
Fujikakwa, K., et al. “Herbicidal activities of phenoxypyridines”, Chemical Abstract (1970), Abstract No. 11080v.
Fujikawa, K., et al., “Studies on Herbicidal Activities of Phenoxypyridines”, Agr. Biol. Chemical, (1970), vol. 34, No. 1 p. 68-79.
DeSouza, E.B., “Corticotropin-releasing Factor Receptors Physiology, Pharmacology, Biochemistry & Role in Central Nervous System & Immune Disorders.”, (1995), vol. 20, No. 8, pp. 789-819.
Fackelmann, K.A. & Raloff, J. “Physological Street Linked to Cancer”, Science News, (Sep. 25, 1993), vol. 144, p. 196.
Lyons, M.K., et al., “Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury”, Brain Research, (1991), vol. 545, Issue 1-2, pp. 339-342.
Stratakis, C.A. & Chrousos, G. P., “Hypothalamic Hormones, GnRH, TRH, CHRH, SRIF, CRH, & Dopamine, Endocrinology” Basic & Clinical Principles, (1997), pp. 185-209 (Humana Press, Tofowa, NJ, 1997).
Strijbos, P. J. L. M., et al. Brain Research, vol. 656, (1991), pp. 405-408.
Robbins, M.J., et al., Can. J. Chem. (1997), vol. 55, pp. 1252-1259.

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