Non-human mammal having a graft and methods of delivering protei

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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424 9321, 424937, 435 691, 800DIG5, 935 60, 935 62, C12N 500, A61K 4800, A01N 6300, C12P 2106

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active

056023014

ABSTRACT:
Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.

REFERENCES:
Acsadi et al (1991) New Biologist 3, 71-81.
Jacobson et al. (1983) Can. J. Physiol. Pharmacol. 61, 1312-1316.
Steinhelper, M. E., Cochrane, K. L. and Field, L. J., "Hypotension In Transgenic Mice Expressing Atrial Natriuretic Factor Fusion Genes", Hypertension, vol. 16, No. 3, pp. 301-307 (1990).
Development, vol. 110, issued 1990, Y. Lallemand et al., "An in situ Asessment of the Routes and Extents of Colonisation of the Mouse Embryonic Stem Cells and their Descendants", pp. 1241-1248, see entire document.
DNA, vol. 5, No. 5, issued 1986, R. J. MacDonald et al., "Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes", pp. 393-401, see entire document.
Science, vol. 254, issued 1991, Dhawan et al., "Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts", pp. 1509-1512.
Brunner, A. M. et al, "Site-Directed Mutagenesis Of Cysteine Residues In The Pro Region Of The Transforming Growth Factor beta 1 Precursor. Expression And Characterization Of Mutant Proteins," J. Biol. Chem., 264(23):13660-13664, 1989.
Delcarpio, J. B., Lanson, N. A., Jr., Field, L. J. and Claycomb, W. C., "Morphological Characterization Of Cardiomyocytes Isolated From A Transplantable Cardiac Tumor Derived From Transgenic Mouse Atria (AT-1 cells)," Circ. Rsrch., 69:1591-1600, 1991.
Field, L. J., "Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors And Cardiac Arrhythmias In Mice," Science, 239:1029-1033, 1988.
Gussoni, E., Pavlath, G. K., Lanctot, A. M., Sharma, K. R., Miller, R. G., Steinman, L. and Blau, H. M., "Normal Dystrophin Transcripts Detected In Duchenne Muscular Dystrophy Patients After Myoblast Transplantation," Nature, 356:435-438, 1992.
Janse, M. J., Cinca, J., Morena, H., Fiolet, J. W., Kleber, A. G., deVries, G. P., Becker, A. E. and Durrer, D., "The Border Zone In Myocardial Ischemia. An Electrophysiological, Metabolic And Histochemical Correlation In The Pig Heart," Circulation Research, 44:576-588, 1979.
Jiao, S., Gurevich, V. and Wolff, J. A., "Long-Term Correction Of Rat Model Of Parkinson's Disease By Gene Therapy", Nature, vol. 362, pp. 450-453 (1993).
Katz, E., Steinhelper, M. E., Daud, A., Delcarpio, J. B., Claycomb, W. C. and Field, L. J. "Cardiomyocyte Proliferation In Mice Expressing .alpha.-Cardiac Myosin Heavy Chain-SV40 T-Antigen Transgenes," Amer. J. Phys., 262 (Heart and Circulatory Physiology 31): H1867-1876, 1992.
Koh, G. Y., Klug, M. G., Soonpaa, M. H., and Field, L. J., "Differentiation And Long-Term Survival of C2C12 Myoblst Grafts In Heart," J. Clin. Invest., vol. 92, Sep. 1993.
Koh, G. Y., Soonpaa, M. H., Klug, M. G. and Field, L. J., "Long-Term Survival Of AT-1 Cardiomyocyte Grafts In Syngeneic Myocardium," Amer. Physiol. Soc., pp. H1727-H1733 (1993).
Loewy, A. D., Bridgman, P. C. and Mettenleiter, T. C., ".beta.-Galactosidase Expressing Recombinant Pseudorabies Virus For Light And Electron Microscopic Study Of Transneuronally Labeled CNS Neurons," Brain Research, 555:346, 1991.
Nadal-Ginard, B., "Commitment, Fusion, And Biochemical Differentiation Of A Myogenic Cell Line In The Absence Of DNA Synthesis," Cell, 15:885-864, 1978.
Rockman, H. A., Ross, R. A., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., Jr. and Chien, K. R., "Segregation Of Atrial-Specific And Inducible Expression Of An ANF Transgene In An in vivo Murine Model Of Cardiac Hypertrophy," Proc. Natl. Acad. Sci., USA, 88:8277-8281, 1991.
Samuel, S. K. et al, "Autocrine Induction Of Tumor Protease Production And Invasion By A Metallothionein-Regulated TGF-beta 1" (Ser223,225), Embo Journal [JC:emb], 11(4):1599-1605, 1992.
Spear, J. F., Michelson, E. L., and More, E. N., "Cellular Electrophysiologic Characteristics Of Chronically Infarcted Myocardium In Dogs Susceptible To Sustained Ventricular Tachyarrhythmias," J. of the Amer. College of Cardiology, 4:1099-1110, 1983.
Steinhelper, M. E., Cochrane, K. L. and Field, L. J., "Hypotension In Transgenic Mice Expressing Atrial Natriuretic Factor Fusion Genes," Hypertension, 16:301-307, 1990.
Steinhelper, M. E. and Field, L. J., "Cardiac Tumors And Dysrhythmias In Transgenic Mice," Toxicologic Pathology, 18:464-469, 1990.
Steinhelper, M. E., Lanson, N., Dresdner, K., Delcarpio, J. B., Wit, A., Claycomb, W. C. and Field, L. J., "Proliferation In Vivo And In Culture Of Differentiated Adult Atrial Cardiomyocytes From Transgenic Mice", Amer. J. Phys., 259 (Heart and Circulatory Physiology 28): H1826-H1834, 1990.
Thompson, L., "Fetal Transplants Show Promise", Science, 257:868-870, 1992.
Yaffe, D., and O. Saxel, "Serial Passaging And Differentiation Of Myogenic Cells Isolated From Dystrophic Mouse Muscle," Nature, 270:725-727, 1977.

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