Gene therapy approaches to supply apolipoprotein A-I...

Details Gene therapy approaches to supply apolipoprotein A-I... Gene therapy approaches to supply apolipoprotein A-I...

2005-01-18

2005-01-18

Saidha, Tekchand (Department: 1652)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S069100, C435S252300, C435S320100, C435S069200, C536S023100, C530S324000

Reexamination Certificate

active

06844327

ABSTRACT:
The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.

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