Solution phase sythesis of arylbenzoxazoles

Details Solution phase sythesis of arylbenzoxazoles Solution phase sythesis of arylbenzoxazoles

2005-03-01

2005-03-01

Celsa, Bennett (Department: 1639)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S217000

Reexamination Certificate

active

06861533

ABSTRACT:
This invention provides methods for the solution-phase synthesis of arylbenzoxazoles. The methods involve condensation of aminophenols with benzaldehydes to form a Schiff base. The Schiff base is then induced to undergo oxidative cyclization in the presence of DDQ. The resulting arylbenzoxazoles can be separated from the reduced DDQ byproduct by treatment of reaction mixture with a strongly basic ion exchange resin.

REFERENCES:
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Varma, R. S.; Saini, R. K.; Prakash, O. “Hypervalent Iodine Oxidation of Phenolic Schiff's Bases: Synthesis of 2-Arylbenzoxazoles” Tetrahedron Letters, 1997, 38(15), 2621-2622.*
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