Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...
Reexamination Certificate
2005-03-15
2005-03-15
Szekely, Peter (Department: 1714)
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Processes of preparing a desired or intentional composition...
C524S558000, C524S559000, C264S166000
Reexamination Certificate
active
06867248
ABSTRACT:
Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.
REFERENCES:
patent: 3982543 (1976-09-01), Schmitt et al.
patent: 4648978 (1987-03-01), Makinen et al.
patent: 4711241 (1987-12-01), Lehmann
patent: 4826493 (1989-05-01), Martini et al.
patent: 4880592 (1989-11-01), Martini et al.
patent: 4910145 (1990-03-01), Holmes et al.
patent: 5236431 (1993-08-01), Gogolewski et al.
patent: 5245023 (1993-09-01), Peoples et al.
patent: 5250430 (1993-10-01), Peoples et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5278256 (1994-01-01), Bellis
patent: 5292860 (1994-03-01), Shiotani et al.
patent: 5334698 (1994-08-01), Witholt et al.
patent: 5480794 (1996-01-01), Peoples et al.
patent: 5489470 (1996-02-01), Noda
patent: 5502116 (1996-03-01), Noda
patent: 5502158 (1996-03-01), Sinclair et al.
patent: 5512669 (1996-04-01), Peoples et al.
patent: 5534432 (1996-07-01), Peoples et al.
patent: 5536564 (1996-07-01), Noda
patent: 5563239 (1996-10-01), Hubbs et al.
patent: 5614576 (1997-03-01), Rutherford et al.
patent: 5625030 (1997-04-01), Williams et al.
patent: 5703160 (1997-12-01), Dehennau et al.
patent: 5705187 (1998-01-01), Unger
patent: 5711933 (1998-01-01), Bichon et al.
patent: 5994478 (1999-11-01), Asrar et al.
patent: 39 37 649 (1991-05-01), None
patent: 39 37 649 (1991-05-01), None
patent: 0 258 781 (1988-03-01), None
patent: 0 258 781 (1988-03-01), None
patent: 0 423 484 (1991-04-01), None
patent: 0 423 484 (1991-04-01), None
patent: 0 601 885 (1994-06-01), None
patent: 0 601 885 (1994-06-01), None
patent: 0 628 586 (1994-12-01), None
patent: 0 628 586 (1994-12-01), None
patent: 0 754 467 (1997-01-01), None
patent: 0 754 467 (1997-01-01), None
patent: 4-326932 (1992-11-01), None
patent: 4-326932 (1992-11-01), None
patent: 5-023189 (1993-02-01), None
patent: 5-023189 (1993-02-01), None
patent: 7-275344 (1995-10-01), None
patent: WO 9218164 (1992-10-01), None
patent: WO 9218164 (1992-10-01), None
patent: WO 9320134 (1993-10-01), None
patent: WO 9320134 (1993-10-01), None
patent: WO 9406886 (1994-03-01), None
patent: WO 9406886 (1994-03-01), None
patent: WO 9503356 (1995-02-01), None
patent: WO 9503356 (1995-02-01), None
patent: WO 9520614 (1995-08-01), None
patent: WO9520614 (1995-08-01), None
patent: WO 9520615 (1995-08-01), None
patent: WO 9520615 (1995-08-01), None
patent: WO 9520621 (1995-08-01), None
patent: WO 9520621 (1995-08-01), None
patent: WO 9523250 (1995-08-01), None
patent: WO 9523250 (1995-08-01), None
patent: WO 9533874 (1995-12-01), None
patent: WO 9533874 (1995-12-01), None
patent: WO 9600263 (1996-01-01), None
patent: WO 9608535 (1996-03-01), None
patent: WO 9608535 (1996-03-01), None
patent: WO 9618420 (1996-06-01), None
patent: WO 9618420 (1996-06-01), None
patent: WO 9804292 (1998-02-01), None
patent: WO 9804292 (1998-02-01), None
patent: WO 9839453 (1998-09-01), None
patent: WO 9839453 (1998-09-01), None
patent: WO 9851812 (1998-11-01), None
patent: WO 9851812 (1998-11-01), None
Agostini, et al., “Synthesis and Characterization of Poly-β-Hydroxybutyrate. I. Synthesis of Crystalline DL Poly-β-Hydroxybutyrate from DL-β-Butyrolactone,”Polym. Sci.Part A-1 9:2775-87 (1971).
Akhtar, “Physiomechanical Properties of bacterial P(HB-HV) Polyesters and Their Uses in drug Delivery,” The British Library Document Supply Centre, UMI, (1990).
Anderson, et al., “Occurrence, Metabolism, metabolic Role, and Industrial Uses of bacterial Polyhydroxyalkanoates,”Microbiological Reviewspp. 450-472 (1990).
Bailey, “Free radical ring-opening polymerization,”J. Polym. Preprints25:210-11 (1984).
Bailey, et al., “Synthesis of Poly-ε-caprolactone via a free radical mechanism. Free radical ring-opening polymerization of 2-methylene-1,3-dioxepane,”J. Polym. Sci. Polym. Chem.20:3021-30 (1982).
Bruhn & Müller, “Preparation and characterization of spray-dried Poly(DL-Lactide) Micro Spheres,”Proceed. Intern. Symp. Control. Rel. Bioact. Mater.18:668-69 (1991).
Byrom, “Miscellaneous Biomaterials” in Biomaterials (D. Byrom, ed.), pp. 333-359 (MacMillan Publishers, London 1991).
Conti, B. et al., “Use of polylactic acid for the preparation of microparticulate drug delivery systems,”J. Microencapsulation9:153-166 (1992).
Cookson, “It grows on trees,”Financial Timesp. 6 (Aug. 12, 1992).
De Smet, et al., “Characterization of intracellular inclusions formed byPseudomonas oleovoransduring growth on octane,”J. Bacteriol.154:870-78 (1983).
Dubois, et al., “Macromolecular Engineering of Polylactones and Polylactides. 12. Study of the Depolymerization Reactions of Poly (ε-caprolactone) with Functional Aluminum Alkoxide End Groups,”Macromolecules26:4407-12 (1993).
Duvernoy, et al., “A biodegradable patch used as a pericardial substitute after cardiac surgery; 6- and 24-month evaluation with CT,”Thorac. Cardiovasc. Surg.43(5):271-74 (1995).
Fukuzaki, et al., “Direct copolymerization of L-lactic acid with γ-butyrolactone in the absence of catalysts,”Die Madromoleculare Chemie190:1553-59 (1989).
Gagnon, et al., “A thermoplastic elastomer produced by the bacteriumPseudomonas oleovarans,” Rubber World207:32-38 (1992).
Gagnon, et al., “Chemical modification of bacterial elastomers: 1. Peroxide crosslinking,”Polymer35:4358-67 (1994).
Gerngross & Martin, “Enzyme-catalyzed synthesis of poly[(R)-(-)-3-hydroxybutyrate]: formation of macroscopic granules in vitro,”Proc. Natl. Acad. Sci. USA92:6279-83 (1995).
Gross, et al., “Polymerization of β-Monosubstituted-β-propiolactones Using Trialkylaluminum-Water Catalytic Systems and Polymer Characterization,”Macromolecules21:2657-68 (1988).
Hein, et al., “Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains ofEscherichia coli., ” FEMS Microbiol. Lett.153:411-18 (1997).
Hocking & Machessault, “Syndiotactic poly[(R,S)-β-hydroxybutyrate] isolated from methyaluminoxane-catalyzed polymerization,”Polym. Bull.30:163-70 (1993).
Hocking & Marchessault, “Biopolyesters” inChemistry and Technology of Biodegradable Polymers,(G.J.L. Griffin, ed.), pp. 48-96, Chapman and Hall: London, 1994.
Holmes, “Biologically Produced (R)-3-hydroxyalkanoate Polymers and Copolymers,” inDevelopments in Crystalline Polymers(Bassett, ed.), pp. 1-65, Elsevier: London, 1988.
Hori, et al., “Chemical synthesis of high molecular weight poly(3-hydroxybutyrate-co-4-hydroxybutyrate),”Polymer36:4703-05 (19
Martin David P.
Skraly Frank
Williams Simon F.
Metabolix Inc.
Pabst Patent Group LLP
Szekely Peter
LandOfFree
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