Fabrication of nanoscale materials using self-assembling protein

Details Fabrication of nanoscale materials using self-assembling protein Fabrication of nanoscale materials using self-assembling protein

1995-05-25

1998-01-27

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

057123667

ABSTRACT:
A method of fabricating nanoscale structural materials via the spontaneous organization of self-assembling proteins and the self-assembling proteins themselves. In a preferred embodiment of the invention, the self-assembling proteins included at least one occurrence of the following recognition sequence: ##STR1## wherein Xaa is a charged residue selected from the group consisting of Glu, Lys, Arg and Asp, and the method comprises admixing proteins which include species of the aforementioned recognition sequence which are prone to dimerization, whereby the admixed proteins are caused to spontaneously organize into nanoscale structural materials via their respective recognition sequences.

REFERENCES:
patent: 4356270 (1982-10-01), Itakura
patent: 4652639 (1987-03-01), Stabinsky
patent: 4704362 (1987-11-01), Itakura et al.
patent: 4748119 (1988-05-01), Rich et al.
patent: 4888286 (1989-12-01), Crea
patent: 5049493 (1991-09-01), Khosla et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5132215 (1992-07-01), Jayaraman et al.
McGrath et al., abstract entitled "Self-Assembling Nanostructures: Recognon and Ordered Assembly in Protein-Based Materials," publ. Nov. 1992, by Materials Research Society in regards to Biomolecular Materials Symposium.
McGrath and Kaplan, DARPA proposal entitled "Controlled Nanostructural Assembly," submitted May 4, 1992.
O'Shea et al., Science, vol. 243, pp. 538-542 (Jan 27, 1989).
O'Shea et al., Science, vol. 245, pp. 646-648 (Aug. 11, 1989).
Lupas et al., Science, vol. 252, pp. 1162-1164 (May 24, 1991).
O'Shea et al., Science, vol. 254, pp. 539-544 (Oct. 25, 1991).
O'Shea et al., X-Ray Structure of the GCN 4 Leucine zipper, a Two Stranded, Parallel Coiled Coil; Science (254) Oct. 1991 539-544.
O'Shea et al.: Preferential Heterodimer Formation by Isolated Leucine Zippers from Fos and Jun.; Science (245) Jun. 1989 646-648.
O'Shea et al.; Evidence That the Leucine Zipper is a Coiled Coil; Science (243) V89578-542.

Affiliated with

Also associated with

Rating

Fabrication of nanoscale materials using self-assembling protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fabrication of nanoscale materials using self-assembling protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fabrication of nanoscale materials using self-assembling protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-343313