Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-03-01
2005-03-01
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300, C536S025300
Reexamination Certificate
active
06861221
ABSTRACT:
The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.
REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4256834 (1981-03-01), Zuk et al.
patent: 4261968 (1981-04-01), Ullman et al.
patent: 4313734 (1982-02-01), Leuvering
patent: 4318707 (1982-03-01), Litman et al.
patent: 4650770 (1987-03-01), Liu et al.
patent: 4713348 (1987-12-01), Ullman
patent: 4853335 (1989-08-01), Olsen et al.
patent: 4868104 (1989-09-01), Kura et al.
patent: 5225064 (1993-07-01), Henkens et al.
patent: 5284748 (1994-02-01), Mroczkowski et al.
patent: 5288609 (1994-02-01), Engelhardt et al.
patent: 5294369 (1994-03-01), Shigekawa et al.
patent: 5360895 (1994-11-01), Hainfeld et al.
patent: 5384073 (1995-01-01), Shigekawa et al.
patent: 5384265 (1995-01-01), Kidwell et al.
patent: 5460831 (1995-10-01), Kossovsky et al.
patent: 5472881 (1995-12-01), Beebe et al.
patent: 5514602 (1996-05-01), Brooks, Jr. et al.
patent: 5521289 (1996-05-01), Hainfeld et al.
patent: 5543158 (1996-08-01), Gref et al.
patent: 5571726 (1996-11-01), Brooks, Jr. et al.
patent: 5599668 (1997-02-01), Stimpson et al.
patent: 5609907 (1997-03-01), Natan
patent: 5637508 (1997-06-01), Kidwell et al.
patent: 5665582 (1997-09-01), Kaushch et al.
patent: 5681943 (1997-10-01), Letsinger et al.
patent: 5751018 (1998-05-01), Alivisatos et al.
patent: 5830986 (1998-11-01), Merrill et al.
patent: 5900481 (1999-05-01), Lough et al.
patent: 5939021 (1999-08-01), Hansen et al.
patent: 5990479 (1999-11-01), Weiss et al.
patent: 6025202 (2000-02-01), Natan
patent: 6149868 (2000-11-01), Natan et al.
patent: 6203989 (2001-03-01), Goldberg et al.
patent: 6251303 (2001-06-01), Bawendi et al.
patent: 6277489 (2001-08-01), Abbott et al.
patent: 6306610 (2001-10-01), Bawendi et al.
patent: 6361944 (2002-03-01), Mirkin et al.
patent: 6365418 (2002-04-01), Wagner et al.
patent: 6417340 (2002-07-01), Mirkin et al.
patent: 0 630 974 (1994-06-01), None
patent: 0 667 398 (1995-08-01), None
patent: WO 8906801 (1989-07-01), None
patent: WO 9002205 (1990-03-01), None
patent: WO 9204469 (1992-03-01), None
patent: Wo 9310564 (1993-05-01), None
patent: WO 9325709 (1993-12-01), None
patent: WO 9740181 (1997-10-01), None
patent: WO 9804740 (1998-02-01), None
patent: WO 9810289 (1998-03-01), None
patent: WO 9817317 (1998-04-01), None
patent: WO 9923258 (1998-10-01), None
patent: WO 9920789 (1999-04-01), None
patent: WO 9921934 (1999-05-01), None
patent: WO 9923258 (1999-05-01), None
patent: WO 9960169 (1999-11-01), None
patent: WO 0100876 (2001-01-01), None
patent: WO 0151665 (2001-07-01), None
patent: WO 0173123 (2001-10-01), None
patent: WO 0186301 (2001-11-01), None
patent: WO 0204681 (2002-01-01), None
patent: WO 0218643 (2002-03-01), None
patent: WO 0236169 (2002-05-01), None
patent: WO 0033079 (2002-06-01), None
patent: WO 0246472 (2002-06-01), None
patent: WO 0246483 (2002-06-01), None
Brada, et al., “Golden Blot”—Detection of Polyclonal and Monoclonal Antibodies Bound to Antigens on Nitrocellulose by Protein A-Gold Complexes,Analytical Biochemistry, vol. 42, pp. 79-83 (1984) U.S.
Dunn, et al., A Novel Method to Map Transcripts: Evidence for homology between an Adenovirus mRNA and Discrete Multiple Regions of the Viral Genome,Cell, vol. 12, pp. 23-36, (1997) U.S.
Hacker, High performance Nanogold—Silver in situ hybridisation,Eur. J. Histochem, vol. 42, pp. 111-120 (1998) U.S.
Ranki, et al., “Sandwich hybridization as a covenient method for the detection of nucleic acids in crude samples,”Gene, vol. 21, pp. 77-85 (1983) U.S.
Romano, et al., “An antiglobulin reagent labelled with colloidal gold for use in electron microscopy,”Immunochemistry, vol. 11, pp. 521-522 (1974) Great Britain.
Borman,Chem.Eng. News, Dec. 9, 1996, pp. 42-43 (1996).
Tomlinson et al.,Anal. Biochem, vol. 171, pp. 217-222 (1998).
Alivisatos et al., “Organization of ‘nanocrystal molecules’ using DNA,”Nature, vol. 382, pp. 609-611 (1996).
Bain, et al., “Modeling Organic Surfaces with Self-Assemble Monolayers,”Angew. Chem. Int. Ed. Engl., vol. 28, pp. 506-512 (1989).
Bradley, “The Chemistry of Transition Metal Colloids,”Clusters and Colloids: From Theory to Applications, G. Schmid, Editor, BCH, Weinheim, New York, pp. 459-542 (1994).
Brust et al., “Novel Gold-Dithiol Nano-Networks with Non-Metallic Electronic Properties,”Adv. Mater., vol. 7, pp. 795-797 (1995).
Chen et al., “A Specific Quadrilateral Synthesized from DNA Branched Junctions,”J. Am. Chem. Soc., vol. 111, pp. 6402-6407 (1989).
Chen & Seeman, “Synthesis from DNA of a molecule with the connectivity of a cube,”Nature, vol. 350, pp. 631-633 (1991).
Chen et al., Crystal Structure of a Four-Stranded Intercalated DNA: d(C4)†‡Biochem., vol. 33, pp. 13540-13546 (1994).
Dagani, “Supramolecular Assemblies DNA to organize gold nanoparticles,”Chemical&Engineering News, p. 6-7, Aug. 19, 1996.
Dubois & Nuzzo, “Synthesis, Structure, and Properties of Model Organic Surfaces,”Annu. Rev. Phys. Chem., vol. 43, pp. 437-464 (1992).
Elghanian et al., “Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles,”Science, vol. 277, pp. 1078-1081 (1997).
Grabar et al., “Preparation and Characterization of Au Colloid Monolayers,”Anal. Chem. vol. 67, pp. 735-743 (1995).
Hacia et al. “Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis,”Nature Genet., vol. 14, pp. 441-447 (1996).
Jacoby, “Nanoparticles change color on binding to nucleotide target,”Chemical&Engineering News, p. 10, Aug. 25, 1997.
Letsinger et al., Use of Hydrophobic Substituents in Controlling Self-Assembly of Oligonucleotides,J. Am. Chem. Soc., vol. 115, pp. 7535-7536 (1993).
Letsinger et al., “Control of Excimer Emission and Photochemistry of Stilbene Units by Oligonucleotide Hybridization,”J. Am. Chem. Soc., vol. 116, pp. 811-812 (1994).
Marsh et al., “A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy,”Nucleic Acids Res., vol. 23, pp. 696-700 (1995).
Mirkin, “H-DNA and Related Structures,”Annu. Review Biophys. Biomol. Struct., vol. 23, pp. 541-576 (1994).
Mirkin et al., “A DNA-based method for rationally assembling nanoparticles into macroscopic materials,”Nature, vol. 382, pp. 607-609 (1996).
Mirkin et al., “DNA-Induced Assembly of Gold Nanoparticles: A Method for Rationally Organizing Colloidal Particles into Ordered Macroscopic Materials,”Abstract249, Abstracts of Papers Part 1, 212 ACS National Meeting 0-8412-3402-7, American Chemical Society, Orlando, FL, Aug. 25-29, 1996.
Mucic et al., “Synthesis and characterizations of DNA with ferrocenyl groups attached to their 5'-termini: electrochemical characterization of a redox-active nucleotide monolayer,”Chem. Commun., pp. 555-557 (1996).
Mulvaney, “Surface Plasmon Sp
Elghanian Robert
Letsinger Robert L.
Mirkin Chad A.
Mucic Robert C.
Storhoff James J.
McDonnell & Boehnen Hulbert & Berghoff
Nanosphere Inc.
Riley Jezia
LandOfFree
Nanoparticles having oligonucleotides attached thereto and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nanoparticles having oligonucleotides attached thereto and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nanoparticles having oligonucleotides attached thereto and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3431372