Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-03-04
1998-01-27
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514404, 514414, 514424, 544141, 544372, 546208, 546281, 5483195, 5483701, 548468, 548550, C07D40306, A61K 31415, A61K 3140
Patent
active
057123004
ABSTRACT:
The present invention provides novel hydroxamic acid derivatives represented by the compound of formula I ##STR1## or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
REFERENCES:
Ghose et al, J. Am. Chem. Soc. 117, (16)4671, 1995.
Gerstl Robert
Pharmacia & Upjohn Company
Yang Lucy X.
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