Viscosity modulating substance and use thereof

Details Viscosity modulating substance and use thereof Viscosity modulating substance and use thereof

2005-07-19

2005-07-19

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S002600, C514S019300, C514S534000, C514S538000, C514S542000, C514S814000, C514S815000, C514S822000, C514S825000

Reexamination Certificate

active

06919374

ABSTRACT:
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced a significant lowering of whole blood viscosity. In vitro addition of APM to patients samples having elevated whole blood viscosity resulted in reduced viscosity over time. These in vivo and in vivo results identify APM as a therapeutic agent for molecular diseases which lead to elevated whole blood viscosity. A method by which APM treatment can be monitored is also disclosed.

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