Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-02-27
1997-04-22
Elliott, George C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 536 253, 536 2789, 536 285, 536 2854, C07H 1906, C07H 19167, C07H 19173, C07H 2100
Patent
active
056230702
ABSTRACT:
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with three or four atom linking groups provide unique oligonucleotide-mimicking macromolecules that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
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Cook Phillip D.
Sanghvi Yogesh S.
Elliott George C.
ISIS Pharmaceuticals Inc.
Larson Thomas G.
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