Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic

Details Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic

1994-12-01

1997-02-11

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

562448, A61K 31195

Patent

active

056021798

ABSTRACT:
There are described optically active derivatives of (R) 5-pentylamino-5-oxopentanoic acid and their pharmaceutically acceptable salts, having antagonistic activity towards cholecystokinin, and with the formula: ##STR1## in which R.sub.1 is selected from the groups 2-naphthyl, 3,4-dichlorophenyl and 3,4-dimethylphenyl and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 carbon atoms, and in which the substituents on the central chiral group (marked with an asterisk in Formula (I)), have the R (rectus) conformation.

REFERENCES:
patent: 4769389 (1988-09-01), Makovec et al.
patent: 4791215 (1988-12-01), Rovati et al.
patent: 4826878 (1989-05-01), Makovec et al.
patent: 4880938 (1989-11-01), Freidinger
European Journal of Medicinal Chemistry, vol. 21, No. 1, 1986. pp. 9-20.
Arznemittel Forschung, vol. 35, No. 7, 1985 pp. 1048-1051.
Organic Chemistry, 3rd Edition, Morrison & Boyd, p. 127.
Chemical Abstracts, vol. 106, #149938b (1987), Makovec, et al.
Chemical Abstracts, vol. 107, #198929 (1987), Makovec, et al.
Chemical Abstracts, vol. 105, #91509 (1986), Makovec, et al.
Chemical Abstracts, vol. 103, #99103r (1985), Makovec, et al.
Kotone, et al., Chemical Abstracts, vol. 81, #121078 (1974).

Affiliated with

Also associated with

Rating

Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-342690