Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving cholesterol
Reexamination Certificate
2005-03-01
2005-03-01
Gitomer, Ralph (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving cholesterol
C435S375000
Reexamination Certificate
active
06861233
ABSTRACT:
The invention relates to methods of identifying therapeutic agents which inhibit triacyglycerol hydrolase (TGH) activity, defined as TGH inhibitors, which are useful in the treatment of conditions resulting from elevated circulating levels of TG, VLDL/LDL-cholesterol and ApoB-100. Also claimed are therapeutic agents which are TGII inhibitors, identifiable by such methods and their use in combating diseases associated with elevated circulating levels of TG, VLDL/LDL-cholesterol and ApoB-100.
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Lehner R., et al., “Subcellullar localization, development expression and characterization of a liver triacyglycerol hydrolase.” Biochemical Journal. 1999;338:761-768.
Lehner R., et al. “Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol.” Biochemical Journal. (Oct. ) 1999;343:1-10R.
Borg-Capra Catherine Sylvia
Lehner Richard Jiri
Vance Dennis Edward
Campen Virginia G.
Gitomer Ralph
Glaxo Group Limited
The Governors of the University of Alberta
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