Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-03
2005-05-03
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S281000
Reexamination Certificate
active
06887895
ABSTRACT:
The invention relates to pseudolaric acid-B derivatives of general formula (I), wherein (a) R1is cyano, heterocyclyl, COXR′ or CON(R″)2, wherein X is O or NH, R′ is H, cycloalkyl, alkyl, heterocyclic alkyl or arylalkyl, each R″ is independently alkyl, cycloalkyl or heterocyclicalkyl; (b) R2is H, alkylacyl, arylalkylacyl, arylacyl or heterocyclylacyl; (c) R3is COXY, amino or halogen, wherein X is O or NH, Y is H, NH2, hydroxy, alkyl, cycloalkyl, heterocyclicalkyl, hetroatom-substituted alkyl, tertiary amino-substituted ammonioalkyl, aryl, arylalkyl or polyhydroxyalkyl. The invention also relates to processes for preparing such derivatives and antitumor or antifungal pharmaceutical compositions containing the same.
REFERENCES:
Pan et al., Planta medica (1990), vol. 56, No. 4, pp. 383-385.
Ding Jian
Xiao Dong
Yang Shengping
Yuan Shengtao
Yue Jianmin
Lowe Hauptman & Berner LLP
Shanghai Institute of Materia Medica Chinese Academy of Science
Solola Taofiq
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