Methods of preventing aggregation of various substances upon...

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Coated – impregnated – or colloidal particulate

Reexamination Certificate

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C424S001110, C424S001330, C424S489000, C424S499000

Reexamination Certificate

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06890512

ABSTRACT:
The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.

REFERENCES:
patent: 3557717 (1971-01-01), Chivers
patent: 3619294 (1971-11-01), Black et al.
patent: 3632357 (1972-01-01), Childs
patent: 3655442 (1972-04-01), Schwer et al.
patent: 4127502 (1978-11-01), Li Mutti et al.
patent: 4158544 (1979-06-01), Louderback
patent: 4327076 (1982-04-01), Puglia et al.
patent: 4327077 (1982-04-01), Puglia et al.
patent: 4457916 (1984-07-01), Hayashi et al.
patent: 4588744 (1986-05-01), McHugh
patent: 4701417 (1987-10-01), Portenhauser et al.
patent: 4762857 (1988-08-01), Bollin, Jr. et al.
patent: 4865871 (1989-09-01), Livesey et al.
patent: 4883762 (1989-11-01), Hoskins
patent: 4891319 (1990-01-01), Roser
patent: 5098893 (1992-03-01), Franks et al.
patent: 5149653 (1992-09-01), Roser
patent: 5242792 (1993-09-01), Rudolph et al.
patent: 5290765 (1994-03-01), Wettlaufer et al.
patent: 5348852 (1994-09-01), Bonderman
patent: 5422384 (1995-06-01), Samuels et al.
patent: 5512547 (1996-04-01), Johnson et al.
patent: 5612315 (1997-03-01), Pikal et al.
patent: 5902565 (1999-05-01), Cox et al.
patent: 0 415 567 (1991-03-01), None
patent: 0 762 897 (1997-03-01), None
patent: 2 009 198 (1979-06-01), None
patent: 2 126 588 (1984-03-01), None
patent: 2 206 273 (1989-01-01), None
patent: WO 8700196 (1987-01-01), None
patent: WO 8906542 (1989-07-01), None
patent: WO 9004329 (1990-05-01), None
patent: WO 9013637 (1990-11-01), None
patent: WO 9202133 (1992-02-01), None
patent: WO 9505809 (1995-02-01), None
patent: WO 9533488 (1995-12-01), None
patent: WO 9640077 (1996-12-01), None
patent: WO 9640077 (1996-12-01), None
Arakawa, T. et al. (1993), “Factors Affecting Short-Term and Long-Term Stabilities of Proteins,”Advanced Drug Delivery Reviews10:1-28.
Carpenter, J. F. et al. (1990). “Comparison of Solute-Induced Protein Stabilization in Aqueous Solution and in the Frozen and Dried States,”J. Dairy Sci. 73(12):3627.3636.
Colaco, C.A.L. S. et al. (1994). “Chemistry of Protein Stabilization by Trehalose” Chapter 14In Formulation and Delivery of Proteins and Peptides, Cleland, J. L. et al. eds. American Chemical Society: Washington, DC. pp. 222-240.
Crowe, J.H. et al. (1990). “Are Freezing and Dehydration Similar Stress Vectors? A Comparison of Modes of Interaction of Stabilizing Solutes with Biomolecules,”Cryobiology27:219-231.
Darnell, J. et al. eds. (1986).Molecular Cell BiologyScientific American Books, Inc. pp. 59.
De Young, L.R. et al. (1993). “Aggregation and Denaturation of Apomyoglobin in Aqueous Urea Solutions,”Biochemistry32:3877-3886.
Heiteftiss, R. et al. (1959). “The Stabilization of Extracts of Cabbage Leaf Proteins by Polyhydroxy Compounds for Electrophoretic and Immunological Studies,”Archives of Biochemistry and Biophysics85:200-208.
Lee, J.C. et al. (1981). “The Stabilization of Proteins by Sucrose,”The Journal of Biological Chemistry256(14):7193-7201.
Manning, M.C. et al. (1989). “Stability of Protein Pharmaceuticals,”Pharmaceutical Research6(l1):903-917.
Newman, Y.M. et al. (1993). “The Role of Trehalose and Other Carbohydrates in Biopreservation”Biotechnology and Genetic Engineering Reviews11(5):263-294.
Paborji, M. et al. (1994). “Chemical and Physical Stability of Chimeric L6, a Mouse-Human Monoclonal Antibody,”Pharmaceutical Research11(5):764-771.
Pikal, M.J. (1991). “Freeze-Drying of Proteins: Part II: Formulation Selection,”Pharmaceutical Technology Internationalpp. 40-43.
Piestrelski, S.J. et al. (1993). “Dehydration-Induced Conformational Transitions in Proteins and Their Inhibition by Stabilizers,”Biophysical Journal65:661-671.
Schwartz, P.L. et al. (1973). “The Aggregation of [125I] Human Growth Hormone in Response to Freezing and Thawing,”EndocrInology92(6):1795-1798.
Anonymous, (1995). “Biochemicals Organic Compounds for Research and Diagnostice Reagents,”SiGMA Chemical Company Catalogue, pp. 995.
Blakeley, D. et al. (Oct. 6, 1990). “Dry Instant Blood Typing Plate for Bedside Use,”Lancet336:854-855.
Burgess, W.H. et al. (1990). “Possible Dissociation of the Heparin-Binding and Mitogenic Activities of Heparin-Binding (Acidic Fibroblast) Growth Factor-1 from its Receptor-Binding Activities by Site-Directed Mutagenesis of a Single Lysine Residue,”J. Cell. Biol. 11:2129-2138.
Colaco, C. et al. (Sept. 1992). “Extraordinary Stability of Enzymes Dried in Trehalose: Simplified Molecular Biology,”BIO/Technol. 10:1007-1011.
Colaco, C. et al. (1992). “Trehalose Stabilisation of Biological Molecules,”Biotechnol. Int'l. pp. 345-350.
Furtado, M.D.F.D. (1991). “Quality Control of Animal Venoms and of Their Correspondent Antivenoms I. Standardization of the Assay Methods to Analyze the Biochemical and Pharmacological Properties of Venoms from Some Snakes Belonging to the Genus Bothrops and Crotalus by Using Samples of Venoms Dried on at Room Temperature or Lyophilized,”Mem. Inst Butantan53(2):149-159. (in original version).
Gillies, S.D. and Wesolowski, J.S. (1990). “Antigen Binding and Biological Activities of Engineered Mutant Chimeric Antibodies with Human Tumor Specificities,”Hum. Antibod. Hybridomas1(l):47-54.
Hora, M.S. (1992). “Lyophilized Formulations of Recombinant Tumor Necrosis Factor,”Pharmaceutical Res. 9(1):33-36.
Hottiger, T. et al. (1994). “The Role of Trehalose Synthesis for the Acquisition of Thermotolerance in Yeast II. Physiological Concentrations of Trehalose Increase the Thermaol Stability of Proteins In Vitro,”Eur. J. Biochem. 219(1-2):187-193.
Ivins, B.E. (Feb. 1992). “Immunization Against Anthrax withBacillus anthracisProtective Antigen Combined with Adjuvants,”Infection&Immunity60(2):662-668.
Lazar, E. et al. (Mar. 1988). “Transforming Growth Factor α: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities,”Mol.&Cell. Biol. 8(3):1247-1252.
Pikal, M.J. et al. (1991). “The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone,”Pharm. Res. 8:427-436.
Roser, B. (Sep. 1991). “Trehalose Drying: A Novel Replacement for Freeze-Drying,”BioPharm. 4:47-53.
Roser, B. (Jul. 1991). “Trehalose, A New Approach to Premium Dried Foods,”Trends in Food Sci.&Technol., pp. 166-169.
Tanford, C. and Reynolds, J.A. (1976). “Characterization of Membrane Proteins in Detergent Solutions,”Biochim. Biophys. Acta457:133-170.
Tanford, C. (1980).The Hydrophobic Effect: Formation of Micelles and Biological Membranes. 2nd Edition, John Wiley & Sons: New York, NY. (Table of Contents Only).
Tao, M. and Morrison, S.L. (Oct. 15, 1989). “Studies of Aglycosylated Chimeric Mouse-Human IgG: Role of Carbohydrate in the Structure and Effector Functions Mediated by the Human IgG Constant Region,”J. of Immunol. 143(8):2595-2601.
Wang, Y.J. et al., eds. (1993).Stability and Characterization of Protein and Peptide Drugs. Plenum Press: New York, NY., pp. 1058.
Yousri, R.M. (1980). “Protein Aggregation in Aqueous Casein Solution; Effect of Irradiation, Dose level, Concentration, Storage, and Additives (Carbohydrate and Lipid,”Z. Ernahrungswiss19(2):111-121.

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