Drug – bio-affecting and body treating compositions – Lymphokine
Reexamination Certificate
2005-01-04
2005-01-04
Saoud, Christine J. (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
C530S351000, C514S012200, C514S814000, C514S885000
Reexamination Certificate
active
06838079
ABSTRACT:
The present invention relates to methods for using various forms of a novel receptor expressed by hematopoietic and endothelial cells. An additional variant form of this receptor has been detected in brain cells and shown to bind to the obese gene product, leptin. Therefore, leptin may be used to stimulate the growth and development of receptor-positive hematopoietic and endothelial cells in vitro and in vivo. In addition, this receptor is selectively expressed in hematopoietic progenitor cells with long-term repopulating potential. Thus, agents that specifically bind to this receptor may be used to identify and isolate progenitor cells for a variety of clinical applications.
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Cioffi Joseph
Shafer Alan Wayne
Snodgrass H. Ralph
Zupancic Thomas Joel
Indevus Pharmaceuticals, Inc.
Jones Day
O'Hara Eileen B.
Saoud Christine J.
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