DNA encoding a human betaine/GABA transporter and uses thereof

Details DNA encoding a human betaine/GABA transporter and uses thereof DNA encoding a human betaine/GABA transporter and uses thereof

1995-10-17

1998-01-27

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

43525411, 4353201, 536 235, C12N 500, C12N 114, C12N 1500, C07H 2104

Patent

active

057121486

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian betaine/GABA transporter, an isolated nucleic acid molecule encoding a human betaine/GABA transporter, an isolated protein which is a mammalian betaine/GABA transporter, an isolated protein which is a human betaine/GABA transporter, vectors comprising an isolated nucleic acid molecule encoding a mammalian betaine/GABA transporter, vectors comprising an isolated nucleic acid molecule encoding a human betaine/GABA transporter, mammalian cells comprising such vectors, antibodies directed to the mammalian betaine/GABA transporter and antibodies directed to the human betaine/GABA transporter, nucleic acid probes useful for detecting nucleic acid molecules encoding mammalian betaine/GABA transporters and human betaine/GABA transporters, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian betaine/GABA transporter or a human betaine/GABA transporter, pharmaceutical compounds related to mammalian and human betaine/GABA transporters, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human betaine/GABA transporter. This invention further provides methods for determining substrate binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with mammalian betaine/GABA transporters and human betaine/GABA transporters.

REFERENCES:
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