Polyamide-oligonucleotide derivatives, their preparation and...

Details Polyamide-oligonucleotide derivatives, their preparation and... Polyamide-oligonucleotide derivatives, their preparation and...

2005-07-19

2005-07-19

Fredman, Jeffrey (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024100, C536S024200, C536S025100, C536S025200, C536S025300, C536S025310, C435S091100, C435S091500

Reexamination Certificate

active

06919441

ABSTRACT:
The invention provides polyamide-oligonucleotide derivatives of the formula:in-line-formulae description="In-line Formulae" end="lead"?F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF′.in-line-formulae description="In-line Formulae" end="tail"?In the formula, q, r, s, and t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s, and t is greater than or equal to 2; and x is 1 to 20. In the formula, DNA is a nucleic acid such as DNA or RNA or a known derivative thereof. Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O, or S. PNA is a polyamide structure which contains at least one nucleotide base that is different from thymine. F and F′ are end groups and/or are linked together by a covalent bond. The invention also provides physiologically tolerated salts of the above formula. The invention further provides a process for preparation of the polyamide-oligonucleotide derivatives of the invention as well as their use as pharmaceuticals, as gene probes, and as primers.

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