Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-09-06
2005-09-06
Ulm, John (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S501000
Reexamination Certificate
active
06939680
ABSTRACT:
This invention provides isolated nucleic acid molecules encoding a human dopamine D1receptor, isolated proteins which are human dopamine D1receptor, vectors comprising isolated nucleic acid molecules encoding a human dopamine D1receptor, mammalian cells comprising such vectors, antibodies directed to a human dopamine D1receptor, nucleic acid probes useful for detecting nucleic acid encoding human dopamine D1receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human dopamine D1receptor, pharmaceutical compounds related to human dopamine D1receptor, and nonhuman transgenic animals which express DNA a normal or a mutant human dopamine D1receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving a human dopamine D1receptor.
REFERENCES:
patent: 4197288 (1980-04-01), Snyder
patent: 4703035 (1987-10-01), Rivier et al.
patent: 5030570 (1991-07-01), Breakefield et al.
patent: 5053337 (1991-10-01), Weinshank et al.
patent: 5427942 (1995-06-01), Civelli et al.
patent: 5686573 (1997-11-01), Civelli et al.
patent: 5882855 (1999-03-01), Weinshank et al.
patent: 9005780 (1990-05-01), None
patent: 9118005 (1991-11-01), None
patent: 9201041 (1992-01-01), None
Bates, M.D., et al., “Molecular Characterization of Dopamine Receptors”,American Journal of Hypertension(1990) 3(6): 29S-33S.
Bunzow, J.R., et al., “Cloning and expression of a rat D2dopamine receptor cDNA”,Nature(1988) 336: 783-787.
Chio, C.L., et al., “A second molecular form of D2dopamine receptor in rat and bovine caudate nucleus”,Nature(1990) 343: 266-269.
Dawson, T.M., et al., “D-1 Dopamine Receptors in the Rat Brain: A Quantitative Autoradiography Analysis”,The Journal of Neuroscience(1986) 6(8): 2352-2365.
Dearry, A., et al., “Molecular cloning and expression of the gene for a human D1dopamine receptor”,Nature(1990) 347: 72-76.
A. Hilditch and G.M. Drew, “Peripheral dopamine receptor subtypes—a closer look”,TIPS(Oct. 1985) pp. 396-400.
J.W. Kebabian and D.B. Caine, “Multiple receptors for dopamine”Nature(1979) 277: 93-96.
O'Dowd, Brian F., “Structures of Dopamine Receptors”J. Neurochem.(1993) 60(3): 804-816.
O'Dowd, B.F., et al., “Cloning of two additonal catecholamine receptors from rat brain”FEBS Letters(1990) 262(1): 8-12.
Senogles, S.E., et al., “Biochemical Properties of D1and D2Dopamine Receptors”,Advances In Experimental Medicine and Biology(1988) 235:33-41.
Sunahara, R.K., et al., “Human dopamine D1receptor encoded by an intronless gene on chromosome 5”,Nature(1990) 347: 80-83.
Sunahara, R.K., et al., “Cloning of the gene for a human dopamine D5receptor with higher affinity for dopamine than D1”,Nature(1991) 350: 614-619.
Van Tol, H.H.M., et al., “Cloning of the gene for a human D4receptor with higher affinity for the antipsychotic clozapine”,Nature(1991) 350: 610-614; and.
Zhou, Q-Y., et al., “Cloning and expression of human and rat D1dopamine receptors”,Nature(1990) 347: 76-79.
U.S. Appl. No. 09/168,510, filed Oct. 8, 1998, Richard L. Weinshank and Paul R. Hartig (Exhibit C).
Grandy, D.K. et al., PNAS USA “Cloning of the cDNA and gene for a human D2 dopamine receptor” (Dec. 1989) 86: 9762-9766.
Grandy, D.K. et al., PNAS USA “Multiple human D5 dopamine receptor genes: A functional receptor and two pseudogenes” (Oct. 1991) 88: 9175-9179.
D.K. Grandy & O. Civelli, Current Opinion in Neurobiology “G-protein-coupled receptors: the new dopamine receptor subtypes” (1992) 2: 275-281.
Hartig Paul R.
Weinshank Richard L.
H. Lundbeck A/S
Kaunchak Stephen G.
Ulm John
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