Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2005-01-25
2005-01-25
Spector, Lorraine (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S350000, C435S023000, C435S023000, C424S001410
Reexamination Certificate
active
06846914
ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding a member of the TIE ligand family. The present invention also provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
REFERENCES:
patent: 5332671 (1994-07-01), Ferrara et al.
patent: 5447860 (1995-09-01), Ziegler
patent: 5521073 (1996-05-01), Davis et al.
patent: WO 9411499 (1994-05-01), None
patent: WO 9611269 (1996-04-01), None
patent: WO 9620403 (1996-07-01), None
patent: WO 9631598 (1996-10-01), None
Valenzuela et al., Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans,Proc. Natl. Acad. Sci. USA, 96(5):1094-1909, Mar. 1999.*
Biochemical and Biophysical Research Communications, vol. 195, No. 1, issued Aug. 31, 1993, Iwama et al.,“Molecular Cloning and Characterization of MouseTIEandTEKReceptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cell”, pp. 301-309.
BLOOD, vol. 80, No. 10, issued Nov. 15, 1992, Korhonen et al.,“Enhanced Expression of thetieReceptor Tyrosine Kinase in Endothelial Cells During Neovascularization”, pp. 2548-2555.
BLOOD, vol. 87, No. 1, issued Jan. 1, 1996, Hashiyama et al., “Predominant Expression of a Receptor Tyrosine Kinase, TIE, in Hematopoietic Stem Cells and B Cells”, pp. 93-101.
BLOOD, vol. 87, No. 6, issued Mar. 15, 1996, Batard et al., “The Tie Receptor Tyrosine Kinase Is Expressed by Hematopoietic Progenitor Cells and by a Subset of Megakaryocytic Cells”, pp. 2212-2220.
Cell, vol. 87, issued Dec. 27, 1996, Davis et al., “Isolation of Angiopoietin-1 a Ligand for the TIE2 Receptor by Secretion-Trap Expression Cloning”, pp. 1161-1169.
Cell, vol. 87, issued Dec. 27, 1996, Suri et al., “Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis”, pp. 1171-1180.
Molecular and Cellular Biology, vol. 12, No. 14, issued Apr. 1992, Partanen et al., “A Novel Endothelial Cell Surface Receptor Tyrosine Kinase with Extracellular Epidermal Growth Factor Homology Domains”, pp. 1698-1707.
Nature, vol. 386, No. 6, issued Jul 6, 1995, Sato et al., “Distinct roles of the receptor tryosine kinases Tie-1 and Tie-2 in blood vessel formation”, pp. 70-74.
Oncogene, vol. 8, 1993, Dumont et al., “ The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors”, pp. 1293-1301.
Oncogene, vol. 8, 1993, Maisonpierre et al., “Distinct rat genes with related profiles of expression define TIE receptor tyrosine kinase family”, pp. 1631-1637.
Proc. Natl. Acad. Sci., vol. 87, issued Nov. 1990, Partanen et al., “Putative tyrosine kinases expressed in K562 human leukemia cells”, pp. 8913-8917.
Proc. Natl. Acad. Sci., vol. 90, issued Oct. 1993, Sato et al.,“tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system”, pp. 9355-9358.
Jones Pamela F.
Valenzuela David M.
Yancopoulos George D.
Gregg, Esq. Valeta
Kaufman Claire M.
Regeneron Pharmaceuticals Inc.
Spector Lorraine
LandOfFree
Tie-2 ligand-3 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tie-2 ligand-3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tie-2 ligand-3 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3402806