Process for reducing the crystal size of ondansetron hydrochlori

Details Process for reducing the crystal size of ondansetron hydrochlori Process for reducing the crystal size of ondansetron hydrochlori

1995-06-07

1997-04-22

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424464, 424465, A61K 914

Patent

active

056227205

ABSTRACT:
The invention relates to a process for reducing the crystal size of ondansetron hydrochloride dihydrate produced by crystallization from solvent to a size which is suitable for effective distribution in a tablet blend, in particular 100% less that 250 .mu.m. The ondansetron hydrochloride dihydrate is desolvated by drying at elevated temperature and reduced or atmospheric pressure and is then rehydrated.

REFERENCES:
patent: 5344658 (1994-09-01), Collin

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