Diarylalkylpiperazines active on the lower urinary tract

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S253090, C514S254090, C514S254110, C514S255030, C544S360000, C544S364000, C544S373000, C544S377000, C544S393000, C544S394000

Reexamination Certificate

active

06894052

ABSTRACT:
Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the administration of the novel compounds of the invention, and other compounds that bind to 5HT1Areceptors, for treating disorders of the lower urinary tract.

REFERENCES:
patent: 3030367 (1962-04-01), Jansen et al.
patent: 3230256 (1966-01-01), Van der Stelt et al
patent: 3435036 (1969-03-01), Regnier et al.
patent: 3457263 (1969-07-01), Regnier et al.
patent: 3472854 (1969-10-01), Archer
patent: 4017624 (1977-04-01), Maruyama et al.
patent: 4060526 (1977-11-01), Shetty
patent: 4092416 (1978-05-01), Winter et al.
patent: 4206213 (1980-06-01), Kleeman et al.
patent: 5177078 (1993-01-01), Ward et al.
patent: 5532242 (1996-07-01), Cliffe et al.
patent: 5723464 (1998-03-01), Brightwell et al.
patent: 5773469 (1998-06-01), Kanojia et al.
patent: 5807856 (1998-09-01), Bock
patent: 5990114 (1999-11-01), Leonardi et al.
patent: 6060038 (2000-05-01), Burns
patent: 6071920 (2000-06-01), Leonardi
patent: 6127357 (2000-10-01), Cliffe et al.
patent: 6686353 (2004-02-01), Shiota et al.
patent: 25 55 290 (1977-06-01), None
patent: 28 00 535 (1978-07-01), None
patent: 0 416 841 (1991-03-01), None
patent: 0 679 642 (1995-04-01), None
patent: 0 711 757 (1996-05-01), None
patent: 0 479 546 (1996-10-01), None
patent: 839 146 (2000-09-01), None
patent: 1 505 109 (1967-12-01), None
patent: 2 295 387 (1996-05-01), None
patent: WO 9315062 (1993-08-01), None
patent: 9504049 (1995-02-01), None
patent: 9605817 (1996-02-01), None
patent: 9743271 (1997-11-01), None
patent: 9744329 (1997-11-01), None
patent: 9906383 (1999-02-01), None
patent: 9952875 (1999-10-01), None
Grant & Hackh's Chemical Dictionary (5th Ed.), p. 14 and 30. 1987.*
Hagan et al,European Journal of Pharmacology, 331,p. 169-174 (Jul. 23, 1997).*
Plilai et al,Indian J. Chem. 14 B,p. 714-716 (1976).*
Patel et al Indian J. Exp. Biol., vol. 9, Jan. 1971, 117-119.
Ananthanarayanan et al., Indian J. of Chem., 12:31-37, Jan. 1974.
Regnier et al., Chimie Therapeutique, May-Jun. 1972, No. 3, 192-205 (English language summary included).
Regnier et al., J. Medicinal Chemistry, 1972, vol. 15, No. 3, 295-301.
Vadodaria, et al., Synthesis and Central Nervous System Depressant Activity of New Piperazine Derivatives and Related Compounds, vol. 12, 860-865.
Mokrosz et al., Arch. Pharm., 328:604(1995).
Barron et al., J. Med. Chem. 8:836-841, 1965.
Abbott, et al., Heterocycles, 40:757, (1995).
Albertson,Org. React. 12,205-218, (1962).
Andersson, Drugs of Today, 24:337-348, (1988).
Andersson,Drugs 35:477, (1988).
Baldwin et al., J. Org. Chem., 47:1386, (1982).
Bliss, C.I.,Quart. J. Pharm. Pharmacolo. 11,192-216, (1938).
Cheng et al., Biochem Pharmacol., 22:3099-3108, 1973.
C, Stockmeier et al. J.Life Sci. 38,117-127, (1983).
Cramer et al., J. Org. Chem., 40:2267, (1975).
De Groat,Neurobiology of Incontinence,Ciba Foundation Symposium151:27, (1990).
DeLean et al., Am. J. Physiol., 235:E97-E102, (1978).
Doherty, et al.,J. Med. Chem 35,2, (1992).
Dray,J. Pharmacol. Methods 13: 157, (1985).
Fargin, et al.,Nature 335,358-360, (1988).
Furstner, Synthesis, 571, (1989).
Greene, T.W., Chapter 7,“Protective Groups in Organic Synthesis”, John Wiley and Sons, New York, (1981).
Guarneri, et al.,Drugs of Today 30:91, (1994).
Guarneri, et al.,Pharmocol. Res., 27:173(1993).
Ishihara,Chem. Pharm. Bull. 39,3236, (1991).
Kleemann et al., Arzn. Forsch., 31:1178, (1981).
Klemm et al., J. Org. Chem., 23:344, (1958).
Lepor,Urology, 42:483, (1993).
Lindley , Tetrahedron, 40:1433, (1984).
Louie et al., J. Org. Chem., 62:1268, (1997).
Maggi, C.A. et al., Brain Res.,380:83, (1986).
Maggi, C.A. et al.,J. Pharmacol. Exp. Ther., 230:500, (1984).
Makosza, Tetrahedron Letter, 673, (1969).
March, Adv. Org. Chem., 4thEd., 1212, (1992).
March , Adv. Org. Chem., 4thEd., 887, (1992).
Marcoux et al., J. Org. Chem., 62:1568, (1997).
Maryanoff et al., Chem. Rev., 89:863, (1989).
McGuire, Campbell's Urology, 5thEd., 616-638, (1986).
Norman et al., J. Med Chem., 39:469, (1996).
Panizzon, Helv. Chim. Acta., 27:1748, (1944).
Perrone et al., II Farmaco., 50:505, (1995).
Pfeiffer et al., Annalen, 581:149, (1953).
Rathke, Org. React., 22:423, (1975).
Ruffman,Int. Med. Res. 16:317, (1988).
Synlett, Note 12:328, (1996).
Vadodaria et al., J. Med Chem., 12:860, (1969).
Wolfe et al., J. Org. Chem., 62:1264, (1997).

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