Process for preparing rac-bicalutamide and its intermediates

Details Process for preparing rac-bicalutamide and its intermediates Process for preparing rac-bicalutamide and its intermediates

2005-03-01

2005-03-01

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C558S411000

Reexamination Certificate

active

06861557

ABSTRACT:
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.

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