Magnesium-substituted hydroxyapatites

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Phosphorus or phosphorus compound

Reexamination Certificate

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C424S604000

Reexamination Certificate

active

06921544

ABSTRACT:
A stable, phase-pure magnesium-substituted crystalline hydroxyapatite containing from about 2.0 to about 29 wt % magnesium, wherein at least 75 wt % of the magnesium content is substituted for calcium ions in the hydroxyapatite lattice structure.

REFERENCES:
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patent: 5830480 (1998-11-01), Ducheyne et al.
patent: 6027742 (2000-02-01), Lee et al.
patent: 97/17285 (1997-05-01), None
patent: 99/32400 (1999-07-01), None
patent: WO00/03747 (2000-01-01), None
Yaoukawa et al. Preparation—Mg-Cahae J. Mater. Chem. 6(8) p. 1401-1405 '96.
Bertoni et al., “Nanocrystals of magnesium and fluoride substituted hydroxyapatite,” J. Inorg. Biochem., 72 (1):29-35 (1998).
Bigi et al., “Magnesium Influence on Hydroxyapatite Crystallization,”J. Inorg. Biochem., 49, 69-78 (1993).

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