Inhibitors of Src and other protein kinases

Details Inhibitors of Src and other protein kinases Inhibitors of Src and other protein kinases

2005-04-26

2005-04-26

Raymond, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S227800, C514S235800, C514S236800, C514S241000, C544S060000, C544S122000, C544S180000, C544S212000, C544S219000, C544S238000, C544S298000, C544S331000

Reexamination Certificate

active

06884804

ABSTRACT:
The present invention provides compounds of formula I:wherein A is N or CR, and G, R1, R2and R3are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

REFERENCES:
patent: WO 0031063 (2000-06-01), None
patent: WO 0222601 (2002-03-01), None
patent: WO 0246184 (2002-06-01), None
Zimmerman, J., et al., “Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC),” Archiv Der Pharmazie, VCH Verlagsgesellschaft MBH, Weinheim, DE, 329(7):371-376 (1996).

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