Contrast agents

Details Contrast agents Contrast agents

2005-07-26

2005-07-26

Jones, Dameron (Department: 1616)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

C424S001110, C424S009100, C424S009200, C424S009300, C424S009500, C548S100000

Reexamination Certificate

active

06921525

ABSTRACT:
The invention provides a composition of matter of the formula (I): V-L-R where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linker moiety or a bond, and R is a moiety detectable in in vivo imaging of a human or animal body, with the provisos that where V is angiotensin or a peptidic angiotensin derivative or analog then V-L-R is other than a non-metal radionuclide substituted peptide (e.g.125I substituted angiotensin II) and L-V is other than simply a peptide with a chelating agent amide bonded to a side chain thereof. This composition of matter may be used to image cardiovascular diseases and disorders.

REFERENCES:
patent: 4411881 (1983-10-01), Tzodikov
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5444069 (1995-08-01), Dudley et al.
patent: 6264914 (2001-07-01), Klaveness et al.
patent: 09 165 377 (1997-06-01), None
patent: 09 165 378 (1997-06-01), None
patent: WO 91 15244 (1991-10-01), None
patent: WO 96 41647 (1996-12-01), None
Bernhart et al., J. Med. Chem., 36(22), 3371-80 (1993).
Wahhab et al., Arzneim.-Forsch. 43(8) 828-30 (1993).
Chemical Abstracts, vol. 127, No. 5 (1997), abstract No. 65770.
Chemical Abstracts, vol. 127, No. 4 (1997), abstract No. 50641.
Sudhir et al., Circulation, 87(3), 931-8 (1993).
Chemical Abstracts, vol. 121, No. 15 (1994), abstract No. 179529.
Model Reactions Targeted at the Synthesis of Carbon 14 Labeled CI-996, a Potent Antagonist of Angiotensin II Receptor (1); Journal of Labelled Compounds and Radiopharmaceuticals, vol.;. XXXIV., No. 3, pp. 213-220, CCC 0362-4803/94/030213-08, 1994 by John Wiley & Sons, Ltd.
Model Reactions Targeted at the Synthesis of Carbon 14 Labeled CI-996, a Potent Antagonist of angiotensin II Receptor (1); Journal of Labelled Compounds and Radiopharmaceuticals , vol. XXXIV., No. 3, pp. 213-220, CCC 0362-4803/94/030213-08, 1994 by John Wiley & Sons, Ltd.

Affiliated with

Also associated with

Rating

Contrast agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Contrast agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Contrast agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3396510