Pediatric rate varying implantable cardiac device

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

Reexamination Certificate

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Reexamination Certificate

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06862475

ABSTRACT:
A device for monitoring cardiac activity in pediatric patients and providing therapeutic stimuli to the pediatric patient such that the basic pacing rate of therapy provided varies so as to closely match the normal variation in a pediatric patient's normal heart rate. In one aspect, the device is initialized with the patient's age at implantation and, via time updates provided by a timer, changes the intrinsic rate of stimulation in accordance with an average heart rate for the patient's age. In another aspect, the device monitors a proxy signal indicative of the patient's age, such as the respiration rate via the minute respiration signal, and varies the intrinsic rate of stimulation in accordance with the proxy indicator of age. In this aspect, the intrinsic stimulation rate is set at a multiple of the respiration rate wherein the multiple is between 6 and 10.

REFERENCES:
patent: 5466254 (1995-11-01), Helland
patent: 5824020 (1998-10-01), Cooper
patent: 5964788 (1999-10-01), Greenhut
Macfarlane, P.W., PhD, FESC, et al.; “Effects of Age, Sex, and Race on ECG Interval Measurements”, Journal of Electrocardiology, vol. 27 Supplement, pp.: 14-19 (1994).
Heragu, Narakesari P., MBBS et al., “Heart Rate Variability in Healthy Children and in Those with Congenital Heart Disease Both Before and After Operation”, The American Journal of Cardiology, vol. 83, pp.: 1654-1657 (Jun. 15, 1999).
Soejima MD, Kyoko et al., “Influence of Age on Ambulatory Electrocardiogram-derived Heart Rate Variability”, Canadian Journal of Cardiology, vol. 15, No. 2, pp.: 142, 181-184, (Feb. 1999).
Gillette, MD, Paul C. et al., “Pediatric Cardiac Pacing”, Cardiology Clinics, vol. 10, No. 4, pp.: 749-754 (Nov. 1992).
Davignon, Andre et al., “Normal ECG Standards for Infants and Children”, Pediatric Cardiology, vol. 1, No. 2, pp.: 124-152 (1979/1980).

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