Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-09-27
2005-09-27
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S245000, C514S269000, C514S274000, C514S275000, C544S122000, C544S212000, C544S296000, C544S330000, C544S331000, C544S332000
Reexamination Certificate
active
06949544
ABSTRACT:
The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
REFERENCES:
patent: WO 95/09847 (1995-04-01), None
patent: WO 97/19065 (1997-05-01), None
patent: WO 01/29009 (2001-04-01), None
patent: WO 02/20495 (2002-03-01), None
patent: WO 02/46170 (2002-06-01), None
patent: WO 02/46171 (2002-06-01), None
CAS printout for Kois et al., Chem Abstract 137:449662 (WO 02/46171).
CAS printout for Davis et al., Chem Abstract 127:81461 (WO 97/19065).
CAs printout for Zimmermann et al., Chem Abstract 123:313996 (WO 95/09847).
Bethiel Randy S.
Cochran John
Moon Young-Choon
Nanthakumar Suganthini
Brown Karen E.
Raymond Richard L.
Vertex Pharmaceuticals Incorporated
Vertex Pharmaceuticals Incorporated
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