Process for the preparation of enantiomerically pure...

Details Process for the preparation of enantiomerically pure... Process for the preparation of enantiomerically pure...

2005-01-04

2005-01-04

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

06838581

ABSTRACT:
The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene;the synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

REFERENCES:
Database CASREACT on STN, Acc. No. 106:84441, Annuziata et al., Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1985), 11, p. 2289-92 (abstract).*
Pandey et al., Tetrahedron Letters 43 (2002), p. 4425-4426.

Affiliated with

Also associated with

Rating

Process for the preparation of enantiomerically pure... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of enantiomerically pure..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of enantiomerically pure... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3391458