Nucleic acids encoding IL13 mutants

Details Nucleic acids encoding IL13 mutants Nucleic acids encoding IL13 mutants

2005-04-26

2005-04-26

Spector, Lorraine (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069100, C530S351000, C530S350000

Reexamination Certificate

active

06884603

ABSTRACT:
This invention provides nucleic acid molecules encoding mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13 molecules include those made by substituting the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Some of the mutants retain the ability to bind and cause signaling through IL13 receptors, while other mutants do not.

REFERENCES:
Debinski et al., Nature Biotechnology 1998, vol. 16, pp. 449-453.

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