Phenyl-substituted indoles and indazoles

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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06872834

ABSTRACT:
The invention features pharmaceutically-active indoles and indazoles that are substituted with phenyl, methods of making them, and methods of using them.

REFERENCES:
patent: 338106 (1886-03-01), Roper
patent: 5385912 (1995-01-01), Neuenschwander et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
patent: WO 9744319 (1997-11-01), None
patent: WO 9806703 (1998-02-01), None
patent: WO 98067703 (1998-02-01), None
patent: WO 9848797 (1998-11-01), None
patent: WO 9848797 (1998-11-01), None
patent: WO 9933822 (1999-07-01), None
patent: WO 0004017 (2000-01-01), None
CAS printout of Plantier et al. (FR M3460).*
CAS printout of Buu-Hoi et al. Chem. Abs. 68:114411, 1968.*
CAS printout of Suh et al. Chem. Abs. 69:77112, 1968.*
CAS printout for Johsi et al.*
CAS printout for Agarwal et al.*
Robert Gastpar, Michael Goldbrunner, Doris Marko and Erwin Von Angerer, “Methoxy-Substituted 3-Formyl-2-phenylindoles Inhibit Tubulin Polymerization”, J. Med. Chem., 1998, pp. 4965-4972, vol. 41.
Brad R. Henke, Kimberley K. Adkinson, Steven G. Blanchard, Lisa M. Lessnitzer, Robert A. Mook, Jr. Kelli D. Plunket, John A. Ray, Claudia Roberson, Rayomand Unwalla and Timothy M. Wilson, “Synthesis and Biological Activity of a Novel Series of Indole-Derived PPAR γ Agonists”, Biooragnic & Medicinal Chemistry Letters 9, 1999, pp. 3329-3334.
George W. Kabalka, Lei Wang, Vasudevan Namboodiri and Richard M. Pagni, “Rapid Microwave-Enhanced, Solventless Sonogashira Coupling Reaction on Alumina”, Tetrahedron Letters 41, 2000, pp. 5151-5154.
Surat Kumar and Shri Nivas Rastogi, “1-[Benzofuranyloxy- & p-(Cyclopent-2-en-1-yl/indolyl)phenoxy]-3-Substituted-amino-propan-2-ols propanes as Potential Biodynamic Agents”, Indian Journal of Chemistry, Jul. 1983, pp. 659-663, vol. 22B.
Kazuhiro Miwa, Toyohiko Aoyama and Takayuki Shioiri, “Extension of the Colvin Rearrangement Using Trimethylsilyldiazomethane. A New Synthesis of Alkynes”, Synlett, Feb. 1994, pp. 107-108.
Yutaka Nishiyama, Ryo Maema, Kengou Ohno, Masaharu Hirose, and Noboru Sonoda, “Synthesis of Indoes: Selenium-Catalyzed Reductive N-Heterocyclization of 2-Nitrostyrenes with Carbon Monoxide”, Tetrahedron Letters, 1999, pp. 5717-5720, vol. 40.
Adrian L. Smith, Graeme I. Stevenson, Christopher J. Swain and Jhose L. Castro, “Traceless Solid Phase Synthesis of 2,3-Disubstituted Indoles”, Tetrahedron Letters 39, 1998, pp. 8317-8320.
Kumiko Takeuchi, Jolie A. Bastian Donetta S. Gifford-Moore, Richard W. Harper, Shawn C. Miller, Jeffrey T. Mullaney, Daniel J. Sall, Gerald F. Smith, Minsheng Zhang and Matthew J. Fisher, “1.2-Disubstituted Indole, Azaindole and Benzimidazole Derivatives Possessng Amine Moiety: A Novel Series of Thrombin Inhibitors”, Bioorganic & Medicinal Chemistry Letters 10, 2000, pp. 2347-2351.
Han-Cheng Zhang, Hong Ye, Allesandro F. Moretto, Kimberly K. Brumfield, and Bruce E. Maryanoff, “Facile Solid-Phase Construction of Indole Derivatives Based on a Traceless, Activating Sulfonyl Linker”, Organic Letters, 2000, pp. 89-92, vol. 2, No. 1.
Han-Cheng Zhang, Kimberly K. Brumfield, Libuse Jaroskova and Bruce E. Maryanoff, “Facile Substitution of Resin-Bound Indoles via the Mannich Reaction”, Tetrahedron Letters 39, 1998, pp. 4449-4452.
PCT International Search Report—International Application No. PCT/US 01/10320—Earliest Priority Date Mar. 31, 2000.
Agarwal, Shiv K. et al., “Synthesis and pharmacological activities of 1-(2,4-disubstituted phenoxy)-3-'NI-(N4-arylpiperazinyl) propanes and 1-(4-chlorobenzoyl)-3-substituted 6-methoxy-2-[4-'3-N1(N4phenylpiperazinyl) propoxy pheny]indoles”; Chemical Abstracts Svc, Colombus, OH, Indian J. Chem., SECT. B (1991), 30B(4) 413-416.

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