Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol

Details Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol

2005-05-17

2005-05-17

Shippen, Michael L. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C560S124000, C564S384000, C564S385000

Reexamination Certificate

active

06894195

ABSTRACT:
A process for the preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol comprising hydrogenating 4-methyl-2,3,5,6-tetrafluorobenzonitrile to 4-methyl-2,3,5,6-tetrafluorobenzylamine and converting 4-methyl-2,3,5,6-tetrafluorobenzylamine to 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol. The process optionally also comprises the further step of reacting 4-Methyl-2,3,5,6-tetrafluobenzyl alcohol with cis-Z-3-(2-chloro-1,1,1-trifluoro-2-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride to the form tefluthrin. 4-Methyl-2,3,5,6-tetrafluorobenzylamine and salts thereof are also claimed.

REFERENCES:
patent: 3406024 (1968-10-01), Richter et al.
patent: 6020517 (2000-02-01), Monzen et al.
patent: 6362372 (2002-03-01), Narizuka et al.
patent: 6452056 (2002-09-01), Kawanobe et al.
patent: 3714602 (1988-11-01), None
patent: 0031199 (1981-07-01), None
patent: 2123823 (1984-02-01), None
patent: 2123824 (1984-02-01), None
patent: 2127013 (1984-04-01), None
patent: 2003089664 (2003-03-01), None
patent: 2003089679 (2003-03-01), None
patent: WO 200017138 (2000-03-01), None
W.C. Groutas, et al., “Inactivation of leukocyte elastase by aryl azolides and sulphonate salts. Structure-activity relationship studies”, Journal of Medicinal Chemistry, vol. 29, No. 7, Jul. 1986, pp. 1302-1303.
J.M. Birchall, et al., “Polyfluoroarenes part IV 2,3,4,5,6-Pentafluorotoluene and related compounds” Journal of The Chemical Society, No. 9, Sep. 1961, pp. 3719-3727.

Affiliated with

Also associated with

Rating

Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3381386