Imidazolophthalazine derivatives as ligands for GABAA receptors

Details Imidazolophthalazine derivatives as ligands for GABAA receptors Imidazolophthalazine derivatives as ligands for GABAA receptors

2005-09-27

2005-09-27

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S234000

Reexamination Certificate

active

06949549

ABSTRACT:
A class of substituted imidazolo[5,1-a]phthalazine derivatives as ligands for GABAAreceptors of formula Iwhich are partial or full inverse agonists of an α5 receptor subunit while being relatively free of activity at α1 and/or α2 and/or α3 receptor subunit binding sites are described herein; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of proconvulsant activity.

REFERENCES:
patent: 6528649 (2003-03-01), Cai et al.
patent: WO 94 22865 (1994-10-01), None
patent: WO 98 04559 (1998-02-01), None
patent: WO 98 37648 (1999-07-01), None
Maubach, Medline Abstract for Current Drug Targets-CNS & Neurological Disorders, vol. 2,p. 233-239 (2003).
X. Zhao, R. Zhang: Synth. Commun., vol. 25, 20, 1995, pp. 3271-3286, XP001033825.

Affiliated with

Also associated with

Rating

Imidazolophthalazine derivatives as ligands for GABAA receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazolophthalazine derivatives as ligands for GABAA receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazolophthalazine derivatives as ligands for GABAA receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3380995