Patched genes and uses related thereto

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S252300, C435S320100, C435S069100, C436S501000, C514S002600, C530S350000, C530S388220, C536S023500

Reexamination Certificate

active

06921646

ABSTRACT:
Invertebrate and vertebrate patched genes are provided, including the mouse and human patched genes, as well as methods for isolation of related genes, where the genes may be of different species or in the same family. Having the ability to regulate the expression of the patched gene, allows for the elucidation of embryonic development, cellular regulation associated with signal transduction by the patched gene, the identification of agonist and antagonist to signal transduction, identification of ligands for binding to patched, isolation of the ligands, and assaying for levels of transcription and expression of the patched gene.

REFERENCES:
patent: 5789543 (1998-08-01), Ingham et al.
patent: 5798209 (1998-08-01), Chan
patent: 5837538 (1998-11-01), Scott
patent: 5935810 (1999-08-01), Friedman et al.
patent: 6027882 (2000-02-01), Scott et al.
patent: WO9611260 (1996-04-01), None
Bowie et al., 1990, Science 247:1306-1310.
Aguirre, A. et al, Biotecnologia Aplicada 13(1)32, 1996.
Forbes-AJ et al., Development 1993 Supplement, pp. 115-124.
Hammerschmidt, M. et al. Protein kinase A is a common negative regulator of Hedgegog signaling in the vertebrate embryo.Genes&Development10, 647-658 (1996).
Noveen, A. et al. cAMP, an Activator of Protein Kinase A, Suppresses the Expression of Sonic Hedgehog.Biochem. Biophys. Res. Comm.219, 180-185 (1996).
Altaba et al., Cell 90:193-196, 1997.
Fan et al., Cell 81(3): 457-465, May 5, 1995.
Krishnan et al., Science 278: 1947-1950, Dec. 12, 1997.
Muller et al., Development 127: 2999-3007, 2000.
Mullins, L.J. & Mullins, J.J. Transgenesis in the Rat and Larger Mammals.J. Clin. Invest.98, S37-S40 (1996).
Ngo, J.T. et al. Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox.Peptide Hormones491-494 (1976).
Rudinger, J. Characteristics of the amino acids as components of a peptide hormone sequence.Endocrinology5-7 (1972).
Seamark R.F. Progress and Emerging Problems in Livestock Transgenesis: a Summary Perspective.Reprod. Fert. Dev.6, 653-657 (1994).
Wall, R.J. Transgenic Livestock: Progress and Prospects for the Future.Theriogenology45, 57-68 (1996).
Akimaru, H. et al., “Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signaling”, Nature 386 (6626): 735-738 (1997).
Akiyama, H. et al., “Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signaling molecules during chondrogenesis and cartilage differentiation in conal mouse EC cells, ATDC5”, Biophys Res. Comm., 235(1): 142-147 (1997).
Alberts, eds., Molecular Biology of the Cell, G-10 (1994).
Alcedo, J. et al., “The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal”, Cell, 86 (2): 221-232 (1996).
Alcedo, J. and Noll, M., “Hedgehog and its patched-smoothened receptor complex: a novel signaling mechanism at the cell surface”, Biol. Chem., 378 (7): 583-590 (1997).
Alexandre, C. et al., “Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cutitus interrptus protein, a member of the GLI family of zinc finger DNA-binding proteins”, Genes Dev., 19 (16): 2003-2013 (1996).
Bale, A., “Variable expressivity of patched mutations in flies and humans”, Am. J. Human Genet., 60 (1): 10-12 (1997).
Bellusci, S. et al., “Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphongenesis”, Development, 124 (1): 53-63 (1997).
Bhat, K. and Schedl, P., “Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched,, gooseberry and wingless during Drosophila neurogenesis”, Development, 124 (9)L 1675-1688 (1997).
Bitgood, M. et al., “Sertoli cell signaling by Desert hedgehog regulates the male germline”, Curr. Biol., 6(3): 298-304 (1996).
Bokor, P. et al., “The roles of hedgehog, wingless and lines in patterning the dorsal epidermis in Drosophila”, Development, 122 (4): 1083-1092 (1996).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions”, Science 247: 1306-1310 (1990).
Cadigan, K. et al., “Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments”, Genes Dev., 8 (8):899-913 (1994).
Chanut, F. and Heberlein, U., “Role of the morphogenetic furow in establishing polarity in the Drosophila eye”, Development, 121 (12): 4085-1094 (1995).
Chavrier et al., “The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach”, Gene 112: 261-264 (1992).
Chen, E. et al., “Compartmental organization of the Drosophila genital imaginal disks”, Development, 124(1): 205-218 (1997).
Chen, Y. et al., “Dual roles for patched in sequestering and transducing Hedgehog”, Cell, 87(3): 553-563 (1996).
Concordet, J. et al., “Spatial regulation of a zebrafish patched homoloogue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning”, Development, 122 (9): 2835-2846 (1996).
Dhawan et al., “Systematic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts”, Science 254: 1509-1512 (1991).
Dominguez, M. et al., “Sending and receiving the hedgehog signal: control by the Drosophila Gli protein cubitus interruptus”, Science, 272 (5268): 1621-1625 (1996).
Echelard, Y. et al., “Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity”, Cell, 75: 1417-1430 (1993).
Epps, J. et al., “Oroshigane,a new segment polarity gene of Drosophila melanogaster, functions in hedgehog signal transduction”, Genetics 145 (4): 1041-1052 (1997).
Epstein, D. et al., “Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway”, Development, 122 (9): 2884-2894 (1996).
Forbes, A. et al., “The role of segment polarity genes during early oogenesis in Drosophila”, Development, 122 (10): 33283-3294 (1996).
Gailani et al., “Developmental Genes and Cancer: Role of Patched in Basal Cell Carcinoma of the Skin”, J. Nat. Canc. Inst. 89 (15): 1103-1109 (1997).
Gailani, M. et al., “The role of the human homologue of Drosophila patched in spradic basal cell carcinomas”, Nat. Genet., 14(1): 78-81 (1996).
Gomez-Skarmeta, J.L. et al. “Araucanandcaupolican.provide a link between compartment subdivisions and pattering of sensory organs and veins in the Drosophila wing”, Genes Dev., 10 (22): 2935-1945 (1996).
Goodrich, L. et al., “Altered neural cell fates and medulloblastoma in mouse patched mutants”, Science, 277 (5329): 1109-1113 (1997).
Goodrich, L. et al., “Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog”, Genes Dev., 10 (3): 301-312 (1996).
Gorlin, R., “Nevoid basal-cell carcinoma syndrome”, Medicine, 66: 98-113 (1987).
Grindley, J. et al., “Evidence for the involvement of the Gli gene family in embryonic mouse lung development”, Dev. Biol., 188 (2): 337-348 (1997).
Habuchi, et al., “Detailed deletion mapping of chromosome 9q bladder cancer: evidence or two tumour suppressor loci”, Oncogene, 11:1671-1674 (1995).
Hahn, H. et al., “A mammalian patched homolog is expressed in target issues of sonic hedgehog and maps to a region associated with development abnormalities”, J. Biol. Chem., 271 (21): 12125-12128 (1996).
Heemskerk, J. et al., “Drosophila hedgehog acts a a morphogen in cellular patterning”, Cell 76: 449-460 (1994).
Hepker, J. et al., “Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes”, Development, 124 (2): 549-558 (1997).
Hidalgo,

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