Induced nuclear reactions: processes – systems – and elements – Nuclear transmutation – By charged particle bombardment
Reexamination Certificate
2005-01-18
2005-01-18
Keith, Jack (Department: 3641)
Induced nuclear reactions: processes, systems, and elements
Nuclear transmutation
By charged particle bombardment
C376S194000, C376S156000
Reexamination Certificate
active
06845137
ABSTRACT:
A system and method for producing18F-Fluoride by using a proton beam to irradiate18Oxygen in gaseous form. The irradiated18Oxygen is contained in a chamber that includes at least one component to which the produced18F-Fluoride adheres. A solvent dissolves the produced18F-Fluoride off of the at least one component while it is in the chamber. The solvent is then processed to obtain the18F-Fluoride.
REFERENCES:
patent: 4622201 (1986-11-01), Robertson et al.
patent: 4794178 (1988-12-01), Coenen et al.
patent: 5280505 (1994-01-01), Hughey et al.
patent: 5425063 (1995-06-01), Ferrieri et al.
patent: 5917874 (1999-06-01), Schlyer et al.
Dahl et al., “Production of radio-isotopes at North Shore Univesity Hospital,” Nuclear Instruments and Methods in Physics Research B 99 (1995), p. 817-820.*
Merriam-Webster's Collegiate Dictionary, Tenth Edition, p. 190.*
Nickles et al., “Production of Reactive Fluorine-18,” Appl. Radiat. Isot., vol. 37, No. 8, pp. 649-661, 1986.*
Firouzbakht et al., A Cryogenic Solid Target for the Production of Fluorine 18 (Fluoride) from Oxygen-18 (Carbon Dioxide), Appl. Radiat. Isot., vol. 44, No. 8, pp. 1081-1084, 1993.*
Lindner et al., “A dynamic Loop Target for the In-Cyclotron Production of Fluorine 18 . . . ”, Appl. Radiat. Isot., vol. 24, No. 8, pp. 124-126, 1973.*
Tilbury et al., “Fluorine-18 Production for Medical Use by Helium-3 Bombardment of Water,” Appl. Radiat. Isot., vol. 21, pp. 277-281, 1970.*
VanBrocklin et al., “High Pressure H2-18O Target for the Production of 18F-Fluoride ion,” Chemists' Views of Imaging Centers, Plenum Press, NY, 1995.*
T.J. Ruth et al., “Targetry for the Production of Ultra High Quantities of 18F-Fluoride: A work in Progress”, abstract from 8thWorkshop on Targetry and Target Chemistry (1999); www.triumf.ca/wtta/pdf/1999/p41.pdf.
N. Satyamurthy, “Oxygen Gas Target System for the Production of Reactive No-Carrier-Added 19F-Fluoride Ion”, Journal of Nuclear Medicine, vol. 5, p. 18p, abstr No. 65 (May 2001).
Pinto, et al., “Target Systems for Radioisotope Production” IEEE Transactions on Nuclear Science, vol. NS-30, No. 2, pp. 1797-1800, Apr. 1983.
Nickles, et al., “An18O2-Target for the High Yield Production of18F-Fluoride”, International Journal of Applied Radiation and Isotopes, vol. 34, No. 3, pp. 625-629, Mar. 1983.
Nickles, et al., An18O2Target for the Production of [18F]F2, International Journal of Applied Radiation and Isotopes, vol. 35, No. 2, pp. 117-122, Feb. 1984.
Iwata Ren, “Target Box for Simultaneous Production of 13NH+4 and 18F”, Publication No. 04077699 dated Mar. 11, 1992 (Japanese Abstract only).
Vandecasteele, et al., “Routine Production of . . . Reaction”, Radiochem. Radioanal. Letters 46/5 pp. 285-290, 19981.
Schlyer, et al., “Separation of . . . Exchange Resin”, Appl. Radial. Isot. vol. 41, No. 6, pp. 531-533, 1990.
Brinkman, “Isotope Production . . . Proton Beams”, International Journal of Applied Radiation and Isotopes, vol. 31, pp. 85-91, 1980.
Bechtold, et al., “Radioisotope für die medizinische Diagnostik”, Nachrichten—Forschungazentrum Kartsruhe Jahrg. 32, Jan. 2, 2000 pp. 10-14.
Adilbish, et al., “123I Production from . . . Medical Research”, International Journal of Applied Radiation and Isotopes, vol. 31, pp. 163-167, 1980.
Chemical Abstracts, vol. 95, 1981; 95: 177334z.
Roberts, et al., “A reevaluation of . . . MeV protons”, Submitted to Applied Radiation and Isotopes, Oct. 5, 1995.
Jewett, et al., “Extraction of . . . Exchange Resin”, Applied Radiation Isotopes, vol. 41, No. 6, pp. 583-586, 1990.
Ruth, et al., “Absolute Cross . . . Reaction”, Radiochimica Acta 26, pp. 21-24, 1979.
Casella, et al., “Anhydrous F-18 . . . Preparation”, The Journal of Nuclear Medicine 21: pp. 750-757, 1980.
Ehrenkaufer, et al., “Production of H18. . . Gas Target”, Radiochimica Acta 33, pp. 49-56, 1983.
Kilbourn, et al., “A Smple18O . . . Production”, International Journal Applied Radiation and Isotopes, vol. 35, No. 7, pp. 599-602, 1984.
Kilbourn, et al., “An Improved . . . Production”, International Journal Applied Radiation and Isotopes, vol. 36, No. 4, pp. 327-328, 1985.
Tewson, et al., “Routine Production . . . Water Target”, Nucl. Med. Biol., vol. 15, No. 5, pp. 499-504, 1988.
Steinbach, et al., “Temperature Course . . . Production”, Applied Radiation Isotopes, vol. 41, No. 8, pp. 753-756, 1990.
Vogt, et al., “Improved Production . . . Nucleophilic Syntheses”, Applied Radiation Isotopes, vol. 37, No. 5, pp. 448-449, 1986.
Keinonen, et al., “Effective Small-Volume . . . Fluoride”, Applied Radiation Isotopes, vol. 37, No. 7, pp. 631-632, 1986.
Iwata, et al., “[18F]Fluoride Production . . . Target”, Applied Radiation Isotopes, vol. 38, No. 11, pp 979-984, 1987.
Nickles, et al., An18O2Target for the Production of [18F]F2, International Journal Applied Radiation and Isotopes, vol. 35, No. 2, pp. 117-122, 1984.
Roberts, et al., Development of an improved target for [18F]F2production, Applied Radiation Isotopes, pp. 1-22, received Aug. 10, 1994.
Steyn, et al., “A Novel Krypton . . . generators”, pp. 104-111.
Hamacher, et al., “Efficient Stereospecific . . . Nucleophilic Substitution”, Journal of Nuclear Medicine, vol. 27, No. 2, pp. 235-238, 1986.
Blessing, et al., “Production of . . . Process”, Applied Radiation Isotopes, vol. 37, No. 11, pp. 1135-1139, 1986.
“A Diagnostic Study of Proton-beam Irradiated Water Targets”, Heselius et al.,Applied Radiation and Isotopes, vol. 40, No. 8 pp. 663-669, 1989.
“A Water Target With Beam Sweet for Routine Fluorine-18 Production”, H.J. Helmeke et al.,Applied Radiation and Isotopes, vol. 54, pp. 753-759, 2001.
“Production of Reactive Fluorine-18”, R. Nickles et al.,Applied Radiation and Isotopes, vol. 37, No. 8, pp. 649-661, 1986.
Buckley Kenneth R.
Chun Kwonsoo
Jivan Salma
Ruth Thomas J.
Zeisler Stefan K.
Harness Dickey
Keith Jack
Palabrica Rick
Triumf
LandOfFree
System and method for the production of 18F-Fluoride does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with System and method for the production of 18F-Fluoride, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method for the production of 18F-Fluoride will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3376213